Controlled release of kaempferol from porous scaffolds augments in-vitro osteogenesis in human osteoblasts

Moorthy, Thrinayan and Hathim, B. Mohamed and NagaMahesh, C. H. Murali and Anburaj, G. and Ahmed, Shiek S. S. J. and Gopinath, Venkatraman and Munuswamy-Ramanujam, Ganesh and Rao, Subha Krishna and Kamath, Manjunath Srinivas (2023) Controlled release of kaempferol from porous scaffolds augments in-vitro osteogenesis in human osteoblasts. Journal of Drug Delivery Science and Technology, 83. ISSN 1773-2247, DOI

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Bone tissue engineering (BTE) is a multidisciplinary approach intending to treat bone abnormalities by using a porous polymer matrix that has the capacity to host cells, promote proliferation and continuously release drugs/ growth factors to enhance bone regeneration. This study fabricated a 3D porous scaffold releasing kaempferol with varying concentrations of kaempferol-entrapped albumin nanoparticles (KaeNP) and polycaprolactone (PCL). The morphology of scaffolds was studied to ensure porous structures and the results revealed that the diameter of pores ranged between 50 mu m-300 mu m which is essential for cell penetration and angiogenesis. Further, X-ray diffraction analysis revealed amorphized form of kaempferol in scaffolds which is beneficial for delivering drugs, as it enhances dissolution. It was observed that kaempferol was controlled released for a period of 20 days. Moreover, the release of kaempferol from scaffolds implies that the concentration of KaeNP alters drug release. In vitro analysis with Human osteoblasts revealed the scaffolds were not toxic and had significant osteogenic potential by virtue of enhancing alkaline phosphatase activity and mineralization. In summary, these scaffolds possessing high osteogenic potential by virtue of controlled kaempferol release will be highly desired for bone tissue engineering.

Item Type: Article
Uncontrolled Keywords: Polycaprolactone; Kaempferol; Bone Tissue engineering; Drug delivery; Controlled release
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Deputy Vice Chancellor (Research & Innovation) Office > Photonics Research Centre
Depositing User: Ms Zaharah Ramly
Date Deposited: 22 Nov 2023 06:18
Last Modified: 22 Nov 2023 06:18

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