Synthesis of I@MPA-Mn:ZnSe as an efficient contrast agent for CT/ fluorescence bi-modal imaging application

Alhasan, Ammar and Sani, S. F. Abdul and Tajuddin, Hairul Anuar and Ali, Tammar Hussein and Hisham, Shameer and Ung, Ngie Min and Azhar, Nurul Amniyyah and Said, Nur Akmarina B. M. and Jamil, Amira Hajirah Abd and Bradley, D. A. (2023) Synthesis of I@MPA-Mn:ZnSe as an efficient contrast agent for CT/ fluorescence bi-modal imaging application. Radiation Physics and Chemistry, 209. ISSN 0969-806X, DOI

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Bi-modal imaging contrast agent has attracted considerable attention in medical physics research field via quantum dots (QDs) fabrications. Doped quantum dots are playing an important role in seeking alternatives to conventional heavy metal-containing particles for medical applications. In order to improve imaging diagnosis, herein we report the design and synthesis of I@MPA-Mn:ZnSe as an efficient contrast agent. The medium, mercaptopropionic acid (MPA) capped Mn:ZnSe QDs surface-conjugated with a commercial contrast agent (Iohexol), was synthesized in seeking to overcome the limitations of Iohexol, also towards advancing bi-modal imaging approaches. In this study, morphology, elemental, absorption and fluorescence analysis were investi-gated, followed by a preliminary study of CT contrast enhancement and cell viability. In comparison to Iohexol, the fluorescence of I@MPA-Mn:ZnSe is observed at 585 nm. The CT Hounsfield unit (HU) increases linearly with mass concentration, with a four-fold increment in HU over that of Iohexol, producing greater than 328 Delta HU at similar concentrations, confirming the CT contrast efficiency of I@MPA-Mn:ZnSe. Cytotoxicity studies have confirmed that the medium possesses good biocompatibility and low toxicity to cells (HepG2 and MDA-MB-321). Present results for CT enhancement and brightness of fluorescence of I@MPA-Mn:ZnSe point to its great potential as a bi-modal contrast medium for further diagnosis applications.

Item Type: Article
Funders: Universiti Malaya under Impact-Oriented Interdisciplinary Research Grant Programme (IIRG) IIRG001B-19FNW, Fundamental Research Grant Scheme (FRGS) of the Ministry of Education Malaysia FRGS/1/2018/STG01/UM/02/14 & FRGS/1/2020/STG05/UM/02/5
Uncontrolled Keywords: Bi-modal; Contrast agent; CT scan; Mn doped ZnSe; Iohexol; Quantum dots
Subjects: Q Science > QC Physics
Q Science > QD Chemistry
Divisions: Faculty of Medicine > Clinical Oncology Department
Faculty of Science > Department of Physics
Faculty of Pharmacy > Department of Pharmaceutical Life Sciences
Depositing User: Ms Zaharah Ramly
Date Deposited: 07 May 2024 04:30
Last Modified: 07 May 2024 04:30

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