Mutation analysis of the BRCA1 gene in Malaysian breast cancer patients

Balraj, P. and Khoo, A.S.B. and Volpi, L. and Tan, J.A.M.A. and Nair, S. and Abdullah, H. (2002) Mutation analysis of the BRCA1 gene in Malaysian breast cancer patients. Singapore Medical Journal, 43 (4). pp. 194-197. ISSN 0037-5675,

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Thirty patients with early onset breast cancer or familial breast cancer from Malaysia were analysed for germline mutation in the early onset breast cancer I gene (BRCA1). Direct sequencing of the entire coding region of BRCA1 identified a frameshift mutation, c.5447-5448insC (insC5447) (codon 1776 of exon 21) in a patient aged 32 of the Malay ethnic origin, who had no family history of breast and/or ovarian cancer. Eight polymorphisms (2201C > T, 2430T > C, P871L, E1038G, K1183R, 4427T > C, S1613G and IVS8-57delT) were identified in the samples tested.

Item Type: Article
Additional Information: Department of Molecular Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA
Uncontrolled Keywords: BRCA1, Breast cancer, Ethnic, Mutation, Malaysian
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms Haslinda Lahuddin
Date Deposited: 08 Oct 2012 03:49
Last Modified: 14 Jan 2019 01:21

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