Antioxidant status following postprandial challenge of two different doses of tocopherols and tocotrienols

Fairus, Syed and Cheng, Hwee Ming and Sundram, Kalyana (2020) Antioxidant status following postprandial challenge of two different doses of tocopherols and tocotrienols. Journal of Integrative Medicine-JIM, 18 (1). pp. 68-79. ISSN 2095-4964, DOI

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Objective: Tocotrienols (T3s) have been hypothesized to have greater antioxidant capacity than tocopherols (Ts) due to differences in biokinetics that affect their absorption and function. The present trial compares the antioxidant effectiveness following postprandial challenge of two different doses of alpha-T or palm T3-rich fraction (TRF) treatments and evaluates their dose-response effects on antioxidant status. Methods: Ten healthy volunteers were given four different doses of vitamin E formulations (268 mg alpha-T, 537 mg alpha-T, 263 mg TRF or 526 mg TRF) in a cross-over postprandial trial. Blood was sampled at 0, 2, 4, 5, 6 and 8 hours after meal consumption and plasma antioxidant status including total glutathione, superoxide dismutase, malondialdehyde (MDA), ferric reducing antioxidant potential and trolox-equivalent antioxidant capacity, was analyzed. Results: Supplementation with the different doses of either alpha-T or TRF did not significantly improve overall antioxidant status. There was no significant difference in overall antioxidant status among treatments at the different doses compared. However, a significant dose-response effect was observed for plasma MDA throughout the 8-hour postprandial period. MDA was significantly lower after the 537 mg alpha-T treatment, compared to the 268 mg alpha-T treatment; it was also lower after the 526 mg TRF treatment compared to the 263 mg TRF treatment (P < 0.05). Conclusion: T3 and alpha-T demonstrated similar antioxidant capacity, despite markedly lower levels of T3 in blood and lipoproteins, compared to alpha-T. (C) 2019 Shanghai Changhai Hospital. Published by Elsevier B.V. All rights reserved.

Item Type: Article
Funders: Malaysian Palm Oil Board (MPOB)
Uncontrolled Keywords: Vitamin E; Tocopherols; Tocotrienols; Antioxidants; Postprandial
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine > Physiology Department
Depositing User: Ms Zaharah Ramly
Date Deposited: 15 Jun 2023 02:24
Last Modified: 15 Jun 2023 02:24

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