Chronic inflammatory diseases at secondary sites ensuing urogenital or pulmonary chlamydia infections

Cheok, Yi Ying and Lee, Chalystha Yie Qin and Cheong, Heng Choon and Looi, Chung Yeng and Wong, Won Fen (2020) Chronic inflammatory diseases at secondary sites ensuing urogenital or pulmonary chlamydia infections. Microorganisms, 8 (1). ISSN 2076-2607, DOI

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Chlamydia trachomatis and C. pneumoniae are members of the Chlamydiaceae family of obligate intracellular bacteria. The former causes diseases predominantly at the mucosal epithelial layer of the urogenital or eye, leading to pelvic inflammatory diseases or blindness; while the latter is a major causative agent for pulmonary infection. On top of these well-described diseases at the respective primary infection sites, Chlamydia are notoriously known to migrate and cause pathologies at remote sites of a host. One such example is the sexually acquired reactive arthritis that often occurs at few weeks after genital C. trachomatis infection. C. pneumoniae, on the other hand, has been implicated in an extensive list of chronic inflammatory diseases which include atherosclerosis, multiple sclerosis, Alzheimer's disease, asthma, and primary biliary cirrhosis. This review summarizes the Chlamydia infection associated diseases at the secondary sites of infection, and describes the potential mechanisms involved in the disease migration and pathogenesis.

Item Type: Article
Funders: Malaysia Ministry of Education Fundamental Research Grant Scheme (FP014-2017A), Universiti Malaya RK014-2018, Malaysia Public Service Department Excellent Student Program Scholarship (PPC)
Uncontrolled Keywords: Chlamydia trachomatis; Chlamydia pneumoniae; Chronic inflammation; Reactive arthritis; Atherosclerosis; Multiple sclerosis; Alzheimer's disease; Primary biliary cirrhosis
Subjects: Q Science > QR Microbiology
R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms Zaharah Ramly
Date Deposited: 16 Jun 2023 07:38
Last Modified: 16 Jun 2023 07:38

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