Transforming growth factor-alpha and nonsyndromic cleft lip with or without palate or cleft palate only in Kelantan, Malaysia

Rahman, R.A. and Ahmad, A. and Rahman, Z.A.A. and Mokhtar, K.I. and Lah, N.A.S.N. and Zilfalil, B.A. and Samsudin, A.R. (2008) Transforming growth factor-alpha and nonsyndromic cleft lip with or without palate or cleft palate only in Kelantan, Malaysia. Cleft Palate-Craniofacial Journal, 45 (6). pp. 583-586. ISSN 1055-6656, DOI


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Objective: To determine the frequency of the transforming growth factor-alpha (TGFα) Taq1 polymorphism in nonsyndromic cleft lip with or without cleft palate (CL±P) and cleft palate only (CP) in Kelantan, Malaysia. Setting: The study was conducted at the Combined Cleft Clinic and at the Human Genome Centre in Hospital Universiti Sains Malaysia in Kelantan, Malaysia. Design: We examined the C2/Taq1 variant of the TGFα gene in 46 patients with nonsyndromic CL±P or CP only and in 33 controls. The TGFα genotype frequencies in patients were compared with those in controls using the chisquare or Fisher exact test. DNA samples were obtained from peripheral blood. Results: No association was found between TGFαTaq1 polymorphism and CL±P or CP in this case-control study. In addition, no homozygosity for the rare allele C2 was noted in CL±P, CP, or the controls. Conclusion: No evidence of TGFαTaq1 polymorphism was observed in association with CL±P and CP in this study.

Item Type: Article
Additional Information: Export Date: 4 September 2012 Source: Scopus CODEN: CPJOE PubMed ID: 18956930 Language of Original Document: English Correspondence Address: Rahman, R. A.; School of Dental Sciences, Universiti Sains Malaysia, 16150 Kota Bharu, Kelantan, Malaysia; email: Chemicals/CAS: Taq Polymerase, EC 2.7.7.-; Transforming Growth Factor alpha References: Ardinger, H.H., Buetow, K.H., Bell, G.I., Bardach, J., Van Demark, D.R., Murray, J.C., Association of genetic variation of the transforming growth factor alpha gene with cleft lip and palate (1989) Am J Hum Genet, 45, pp. 348-353; Boo, N.Y., Arshad, A.R., A study of cleft lip and palate in neonates born in a large Malaysian maternity hospital over a 2-year period (1990) Singapore Med J, 31, pp. 59-62; Chevenix-Trench, G., Jones, K., Green, A.C., Duffy, D.L., Martin, N.G., Cleft lip with or without cleft palate: Associations with transforming growth factor alpha and retinoic acid receptor loci (1992) Am J Hum Genet, 51, pp. 1377-1385; Dixon, M.J., Garner, J., Ferguson, M.W.J., Immunolocalisation of epidermal growth factor (EGF), EGF receptor and transforming growth alpha (TGFa) during murine palatogenesis in vitro and in vivo (1991) Anat Embryol, 184, pp. 83-91; Edison, R.J., Muenke, M., Central nervous system and limb anomalies in case reports of first-trimester statin exposure (2004) N Engl J Med, 350, pp. 1579-1582; FitzPatrick, D.R., Carr, I.M., McLaren, L., Leek, J.P., Wightman, P., Williamson, K., Gautier, P., Firth, H., Identification of SATB2 as the cleft palate gene on 2q32-q33 (2003) Hum Mol Genet, 12, pp. 2491-2501; Hart, T.C., Marazita, M.L., Wright, J.T., The impact of molecular genetics on oral health paradigms (2000) Crit Rev Oral Biol Med, 11, pp. 26-56; Holder, S.E., Vintiner, G.M., Farren, B., Malcolm, S., Winter, R.M., Confirmation of an association between RFLPs at the transforming growth factor-alpha locus and non-syndromic cleft lip and palate (1992) J Med Genet, 29, pp. 390-392; Hwang, S.J., Beaty, T.H., Panny, S.R., Street, N.A., Joseph, J.M., Gordon, S., McIntosh, I., Francoman, C.A., Association study of transforming growth factor alpha Taq 1 polymorphism and oral clefts: Indication of gene-environment interaction in a population-based sample of infants with birth defect (1995) Am J Epidemiol, 141, pp. 629-636; Jones, M.C., Etiology of facial clefts: Prospective evaluation of 428 patients (1988) Cleft Palate J, 25, pp. 16-20; Khoury, M.J., Gomez-Farias, M., Mulinare, J., Does maternal cigarette smoking during pregnancy cause cleft lip and palate in offsprings? 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Uncontrolled Keywords: Cleft lip with or without cleft palate Rare allele C2 TGFα transforming growth factor alpha adolescent adult article child cleft lip cleft palate comparative study controlled study DNA determination DNA polymorphism female gene genetic variability genotype human infant major clinical study Malaysia male priority journal taq1 gene Case-Control Studies Child, Preschool Gene Frequency Humans Polymorphism, Restriction Fragment Length Taq Polymerase Young Adult
Subjects: R Medicine > RK Dentistry
Divisions: Faculty of Dentistry > Dept of Oral & Maxillofacial Surgery
Depositing User: Mr Ahmad Azwan Azman
Date Deposited: 24 Sep 2012 01:43
Last Modified: 24 Sep 2012 01:43

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