A nanotechnological approach for enhancing the topical drug delivery by newly developed liquid crystal formulations

Kadhum, Wesam R. and Al-Zuhairy, Saeed A.S. and Mohamed, Masar B.M. and Abdulrahman, Ammar Yasir and Kadhim, Mustafa M. and Alsadoon, Zeid and Teoh, Teoh C. (2021) A nanotechnological approach for enhancing the topical drug delivery by newly developed liquid crystal formulations. International Journal of Drug Delivery Technology, 11 (3). pp. 716-720. ISSN 0975-4415, DOI https://doi.org/10.25258/ijddt.11.3.11.

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Transdermal drug administration is a great substitute to oral medication administration. Inadequate penetration of active pharmaceuticals via the skin, on the other hand, is a common phenomenon. As a result, we investigated the ability of liquid crystal (LC) topical formulations to improve skin penetration in the current study. LC-forming lipids are a significant class of biocompatible amphiphiles with applications in cosmetic, dietary, and medicinal technologies. Just a few experiments have looked into how the concentration of LC-forming lipids affects the ability of drugs to reach the skin following topical application. We initially prepared LC formulations of p-aminobenzoic acid (PABA) as a hydrophilic drug mode (The homogeneity and viscosity of the prepared formulations is determined). Additionally, we used a Zetasizer to determine the zeta potential and particle size of LC formulations. The dialysis procedure was used to determine the liberation of drugs from LC formulations. In-vitro skin penetration tests were conducted to decide if LC formulations could increase skin penetration and concentration. By understanding the influence of the LC-forming lipid concentration used in the LC preparation, researchers might establish LC formulation methods that increase drug skin penetration. © 2021, Dr. Yashwant Research Labs Pvt. Ltd.. All rights reserved.

Item Type: Article
Funders: None
Uncontrolled Keywords: LC-forming lipids; Liquid crystal; Penetration of skin; Topical drugs
Subjects: R Medicine
R Medicine > RM Therapeutics. Pharmacology > Drug prescribing
Divisions: Faculty of Medicine
Depositing User: Ms Zaharah Ramly
Date Deposited: 17 Oct 2023 06:08
Last Modified: 17 Oct 2023 06:08
URI: http://eprints.um.edu.my/id/eprint/35497

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