In vitro activity of tigecycline against Acinetobacter baumannii isolates from a teaching hospital in Malaysia

Dhabaan, G.N. and AbuBakar, Sazaly and Shorman, M.A. and Hassan, H. (2012) In vitro activity of tigecycline against Acinetobacter baumannii isolates from a teaching hospital in Malaysia. Journal of Chemotherapy, 24 (2). pp. 87-92.

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The In vitro susceptibility of clinical and environmental isolates of Acinetobacter baumannii to tigecycline and other antibiotics was determined by disk diffusion method. The E-test was used to determine the minimum inhibitory concentration (MIC). The growth curves of tigecycline treated environmental and clinical strains were established. Fifty-seven percent and 75 of the clinical and environmental isolates were MDR strains, respectively. Ninety-five percent of the clinical isolates were susceptible to tigecycline and 5 showed intermediate resistance with MIC ranging between 0·032 and 3 mg/l. Tigecycline susceptible and intermediate resistance among the environmental isolates were 40 and 60, respectively, with a significantly lower MIC range of 0·5�4 mg/l. The bacterial growth curves demonstrated the higher ability of the environmental strains to tolerate the antibiotic effects than the clinical strains. The relatively high resistance profile among the environmental isolate suggests an insidious emergence of tigecycline resistance amongst A. baumannii. Strict infection control procedures are imperative to prevent the dissemination of tigecycline-resistant A. baumannii strains in the hospital environment.

Item Type: Article
Additional Information: Correspondence to: H Hassan Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. Email:
Uncontrolled Keywords: Antimicrobial resistance; Tigecycline; Acinetobacter baumannii
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: hamimah hamimah hassan
Date Deposited: 06 Aug 2012 01:07
Last Modified: 13 Feb 2019 08:32

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