Mucosal-associated invariant T cells: Diplomatic front-runners in the fight against hepatitis B virus infection

Tan, Hong-Yien and Yong, Yean-Kong and Ng, Chen Seng and Vimali, Jaisheela and Mohamed, Rosmawati and Murugesan, Amudhan and Velu, Vijayakumar and Larsson, Marie and Shankar, Esaki M. (2021) Mucosal-associated invariant T cells: Diplomatic front-runners in the fight against hepatitis B virus infection. Critical Reviews in Immunology, 41 (5). pp. 1-17. ISSN 1040-8401, DOI

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Mucosal-associated invariant T (MAIT) cells are a unique subset of innate-like T cells that bridge between innate and adaptive immunity. MALT cells act like a `biliary firewall' protecting the epithelial lining of the liver against pathogenic intruders. MAIT1 and MAIT17 subsets respond rapidly to pathogenic presence both in the liver as well as in the peripheral circulation. In addition to chronic hepatitis B virus (HBV) infection, MAIT cells also appear to serve as potential therapeutic targets in several other chronic ailments. Evidence indicates that MAIT cells have tissue repair functions also paving way for fibrotic changes during chronic HBV infection. Observations also suggest that HBV-hepatitis delta virus (HDV) co-infection disease progression is closely associated with loss of MAIT cells. Furthermore, reduction in the number of hepatic MAIT cells in patients with cirrhotic non-alcoholic fatty liver disease and HBV-associated primary liver cancer has also been reported. Given their concrete role against HBV disease progression, and has also become evident that the tumor microenvironment can cause functional impairment of MAIT cells. Here, we reviewed the protective and the pathological role of MAIT cells in chronic HBV infection and certain other related medical conditions based on the understanding that an optimal functioning of the MAIT cell arsenal is key to a ``host-friendly'' immune defense against HBV disease progression.

Item Type: Article
Funders: Xiamen University Malaysia Research Funding (XMUMRF)[XMUMRF/2020-C5/ITCM/0003], Xiamen University Malaysia Research Funding (XMUMRF)[XMUMRF/2018-C2/ILAB/0001], Department of Science and Technology-Science and Engineering Research Board, Government of India[CRG/2019/006096], Swedish Research Council European Commission[AI52731], Swedish Physicians against AIDS Research Foundation, Swedish International Development Cooperation Agency, SIDA SARC, Vinnova, Linkoping University Hospital Research Fund, Swedish Society of Medicine, CALF
Uncontrolled Keywords: MAIT cell;HBV;NAFLD;Hepatocellular carcinoma;Immunotherapy
Subjects: Q Science > QR Microbiology > QR180 Immunology
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculty of Medicine
Depositing User: Ms Zaharah Ramly
Date Deposited: 26 Oct 2022 01:58
Last Modified: 26 Oct 2022 01:58

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