IAEA activities on Cu-67,Re-186, Sc-47 theranostic radionuclides and radiopharmaceuticals

Jalilian, Amir R. and Gizawy, Mohamed A. and Alliot, Cyrille and Takacs, Sandor and Chakarborty, Sudipta and Rovais, Mohammad R. A. and Pupillo, Gaia and Nagatsu, Kotaro and Park, Jeong H. and Khandaker, Mayeen Uddin and Mikolajczak, Renata and Bilewicz, Aleksander and Okarvi, Subhani and Gagnon, Katherine and Al Rayyes, Abdul H. and Lapi, Suzanne E. and Starovoitova, Valeriia and Korde, Aruna and Osso, Joao A. (2021) IAEA activities on Cu-67,Re-186, Sc-47 theranostic radionuclides and radiopharmaceuticals. Current Radiopharmaceuticals, 14 (4). pp. 306-314. ISSN 1874-4710, DOI https://doi.org/10.2174/1874471013999200928162322.

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Despite interesting properties, the use of Cu-67, Re-186 and Sc-47 theranostic radionuclides in preclinical studies and clinical trials is curtailed by their limited availability due to a lack of widely established production methods. An IAEA Coordinated Research Project (CRP) was initiated to identify important technical issues related to the production and quality control of these emerging radionuclides and related radiopharmaceuticals, based on the request from IAEA Member States. The international team worked on targetry, separation, quality control and radiopharmaceutical aspects of the radionuclides obtained from research reactors and cyclotrons leading to preparation of a standard recommendations for all Member States. The CRP was initiated in 2016 with fourteen participants from thirteen Member States from four continents. Extraordinary results on the production, quality control and preclinical evaluation of selected radionuclides were reported in this project that was finalized in 2020. The outcomes, outputs and results of this project achieved by participating Member States are described in this minireview.

Item Type: Article
Funders: international IAEA/CRP [F22053], DOE Isotope Program [DE-SC0020197], Polish Ministry of Science and Higher Education research funds [3639/FAO/IAEA/16/2017/0] [3574/IAEA/2016/0], CERAD project, Smart Growth Operational Programme 2014-2020, Priority IV, Measure 4.2. [POIR.04.02.00-14-A001/16], NRF [2017M2A2A6A05016600], Nuclear RD Program
Uncontrolled Keywords: Cu-67; Re-186; Sc-47; IAEA; CRP; Theranostic; Research reactor; Cyclotron
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Science > Department of Physics
Depositing User: Ms Zaharah Ramly
Date Deposited: 11 May 2022 02:04
Last Modified: 11 May 2022 02:04
URI: http://eprints.um.edu.my/id/eprint/34982

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