Global respiratory syncytial virus-related infant community deaths

Mazur, Natalie and Lowensteyn, Yvette N. and Willemsen, Joukje E. and Gill, Christopher J. and Forman, Leah and Mwananyanda, Lawrence M. and Blau, Dianna M. and Breiman, Robert F. and Madhi, Shabir A. and Mahtab, Sana and Gurley, Emily S. and El Arifeen, Shams and Assefa, Nega and Scott, J. Anthony G. and Onyango, Dickens and Barr, Beth A. Tippet and Kotloff, Karen L. and Sow, Samba O. and Mandomando, Inacio and Ogbuanu, Ikechukwu and Jambai, Amara and Bassat, Quique and Caballero, Mauricio T. and Polack, Fernando P. and Omer, Saad and Kazi, Abdul Momin and Simoes, Eric A. F. and Satav, Ashish and Bont, Louis J. and Network, CHAMPS and Grp, RSV GOLD Study (2021) Global respiratory syncytial virus-related infant community deaths. Clinical Infectious Diseases, 73 (3). S229-S237. ISSN 1058-4838, DOI

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Respiratory syncytial virus (RSV) is a leading cause of pediatric death, with >99% of mortality occurring in lowand lower middle-income countries. At least half of RSV-related deaths are estimated to occur in the community, but clinical characteristics of this group of children remain poorly characterized. Methods. The RSV Global Online Mortality Database (RSV GOLD), a global registry of under-5 children who have died with RSV-related illness, describes clinical characteristics of children dying of RSV through global data sharing. RSV GOLD acts as a collaborative platform for global deaths, including community mortality studies described in this supplement. We aimed to compare the age distribution of infant deaths <6 months occurring in the community with in-hospital. Results. We studied 829 RSV-related deaths <1 year of age from 38 developing countries, including 166 community deaths from 12 countries. There were 629 deaths that occurred <6 months, of which 156 (25%) occurred in the community. Among infants who died before 6 months of age, median age at death in the community (1.5 months; IQR: 0.8-3.3) was lower than in-hospital (2.4 months; IQR: 1.5-4.0; P <.0001). The proportion of neonatal deaths was higher in the community (29%, 46/156) than in-hospital (12%, 57/473, P < 0.0001). Conclusions. We observed that children in the community die at a younger age. We expect that maternal vaccination or immunoprophylaxis against RSV will have a larger impact on RSV-related mortality in the community than in-hospital. This case series of RSV-related community deaths, made possible through global data sharing, allowed us to assess the potential impact of future RSV vaccines.

Item Type: Article
Funders: Bill & Melinda Gates Foundation CGIAR[OPP1148988.8]
Uncontrolled Keywords: Community death;Lower respiratory tract infection; Respiratory syncytial virus
Subjects: R Medicine
R Medicine > R Medicine (General)
Depositing User: Ms Zaharah Ramly
Date Deposited: 15 Jun 2022 02:16
Last Modified: 15 Jun 2022 02:16

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