Strategies for the use of Ginkgo biloba extract, EGb 761(R), in the treatment and management of mild cognitive impairment in Asia: Expert consensus

Kandiah, Nagaendran and Chan, Yee Fai and Chen, Christopher and Dasig, Darwin and Dominguez, Jacqueline and Han, Seol-Heui and Jia, Jianping and Kim, SangYun and Limpawattana, Panita and Ng, Li-Ling and Nguyen, Dinh Toan and Ong, Paulus Anam and Raya-Ampil, Encarnita and Saedon, Nor'izzati and Senanarong, Vorapun and Setiati, Siti and Singh, Harjot and Suthisisang, Chuthamanee and Trang, Tong Mai and Turana, Yuda and Venketasubramanian, Narayanaswamy and Yong, Fee Mann and Youn, Yong Chul and Ihl, Ralf (2021) Strategies for the use of Ginkgo biloba extract, EGb 761(R), in the treatment and management of mild cognitive impairment in Asia: Expert consensus. CNS Neuroscience & Therapeutics, 27 (2). pp. 149-162. ISSN 1755-5930, DOI

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Background Mild cognitive impairment (MCI) is a neurocognitive state between normal cognitive aging and dementia, with evidence of neuropsychological changes but insufficient functional decline to warrant a diagnosis of dementia. Individuals with MCI are at increased risk for progression to dementia; and an appreciable proportion display neuropsychiatric symptoms (NPS), also a known risk factor for dementia. Cerebrovascular disease (CVD) is thought to be an underdiagnosed contributor to MCI/dementia. The Ginkgo biloba extract, EGb 761 (R), is increasingly being used for the symptomatic treatment of cognitive disorders with/without CVD, due to its known neuroprotective effects and cerebrovascular benefits. Aims To present consensus opinion from the ASian Clinical Expert group on Neurocognitive Disorders (ASCEND) regarding the role of EGb 761 (R) in MCI. Materials & Methods The ASCEND Group reconvened in September 2019 to present and critically assess the current evidence on the general management of MCI, including the efficacy and safety of EGb 761 (R) as a treatment option. Results EGb 761 (R) has demonstrated symptomatic improvement in at least four randomized trials, in terms of cognitive performance, memory, recall and recognition, attention and concentration, anxiety, and NPS. There is also evidence that EGb 761 (R) may help delay progression from MCI to dementia in some individuals. Discussion EGb 761 (R) is currently recommended in multiple guidelines for the symptomatic treatment of MCI. Due to its beneficial effects on cerebrovascular blood flow, it is reasonable to expect that EGb 761 (R) may benefit MCI patients with underlying CVD. Conclusion As an expert group, we suggest it is clinically appropriate to incorporate EGb 761 (R) as part of the multidomain intervention for MCI.

Item Type: Article
Funders: Schwabe Pharma Asia Pacific Pte Ltd, Dr Willmar Schwabe GmbH Co. KG
Uncontrolled Keywords: Cerebrovascular disease; Dementia; EGb 761(&#174); Ginkgo biloba; Mild cognitive impairment; Neuropsychiatric symptoms
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Faculty of Medicine > Medicine Department
Depositing User: Ms Zaharah Ramly
Date Deposited: 14 Sep 2022 00:35
Last Modified: 14 Sep 2022 00:35

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