Association of body mass index with immune recovery, virological failure and cardiovascular disease risk among people living with HIV

Han, W. M. and Jiamsakul, A. and Jantarapakde, J. and Yunihastuti, E. and Choi, J. Y. and Ditangco, R. and Chaiwarith, R. and Sun, L. P. and Khusuwan, S. and Merati, T. P. and Do, C. D. and Raja Azwa, Raja Iskandar Shah and Lee, M-P and Van Nguyen, K. and Chan, Y-J and Kiertiburanakul, S. and Ng, O. T. and Tanuma, J. and Pujari, S. and Zhang, F. and Gani, Y. M. and Sangle, S. and Ross, J. and Kumarasamy, N. (2021) Association of body mass index with immune recovery, virological failure and cardiovascular disease risk among people living with HIV. HIV Medicine, 22 (4). pp. 294-306. ISSN 1464-2662, DOI

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Objectives We conducted a longitudinal cohort analysis to evaluate the association of pre-treatment body mass index (BMI) with CD4 recovery, virological failure (VF) and cardiovascular risk disease (CVD) markers among people living with HIV (PLHIV). Methods Participants who were enrolled between January 2003 and March 2019 in a regional Asia HIV cohort with weight and height measurements prior to antiretroviral therapy (ART) initiation were included. Factors associated with mean CD4 increase were analysed using repeated-measures linear regression. Time to first VF after 6 months on ART and time to first development of CVD risk markers were analysed using Cox regression models. Sensitivity analyses were done adjusting for Asian BMI thresholds. Results Of 4993 PLHIV (66% male), 62% had pre-treatment BMI in the normal range (18.5-25.0 kg/m(2)), while 26%, 10% and 2% were underweight (< 18.5 kg/m(2)), overweight (25-30 kg/m2) and obese (> 30 kg/m(2)), respectively. Both higher baseline and time-updated BMI were associated with larger CD4 gains compared with normal BMI. After adjusting for Asian BMI thresholds, higher baseline BMIs of 23-27.5 and > 27.5 kg/m(2) were associated with larger CD4 increases of 15.6 cells/mu L 95% confidence interval (CI): 2.9-28.3] and 28.8 cells/mu L (95% CI: 6.6-50.9), respectively, compared with normal BMI (18.5-23 kg/m(2)). PLHIV with BMIs of 25-30 and > 30 kg/m(2) were 1.27 times (95% CI: 1.10-1.47) and 1.61 times (95% CI: 1.13-2.24) more likely to develop CVD risk factors. No relationship between pre-treatment BMI and VF was observed. Conclusions High pre-treatment BMI was associated with better immune reconstitution and CVD risk factor development in an Asian PLHIV cohort.

Item Type: Article
Funders: United States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH National Institute of Allergy & Infectious Diseases (NIAID)
Uncontrolled Keywords: Body mass index;Cardiovascular risks;HIV;Immune recovery; Virological response
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms Zaharah Ramly
Date Deposited: 13 Jun 2022 01:41
Last Modified: 13 Jun 2022 01:41

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