Current status of endoplasmic reticulum stress in type II diabetes

Mustapha, Sagir and Mohammed, Mustapha and Azemi, Ahmad Khusairi and Jatau, Abubakar Ibrahim and Shehu, Aishatu and Mustapha, Lukman and Aliyu, Ibrahim Muazzamu and Danraka, Rabi'u Nuhu and Amin, Abdulbasit and Bala, Auwal Adam and Ahmad, Wan Amir Nizam Wan and Rasool, Aida Hanum Ghulam and Mustafa, Mohd Rais and Mokhtar, Siti Safiah (2021) Current status of endoplasmic reticulum stress in type II diabetes. Molecules, 26 (14). ISSN 1420-3049, DOI

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The endoplasmic reticulum (ER) plays a multifunctional role in lipid biosynthesis, calcium storage, protein folding, and processing. Thus, maintaining ER homeostasis is essential for cellular functions. Several pathophysiological conditions and pharmacological agents are known to disrupt ER homeostasis, thereby, causing ER stress. The cells react to ER stress by initiating an adaptive signaling process called the unfolded protein response (UPR). However, the ER initiates death signaling pathways when ER stress persists. ER stress is linked to several diseases, such as cancer, obesity, and diabetes. Thus, its regulation can provide possible therapeutic targets for these. Current evidence suggests that chronic hyperglycemia and hyperlipidemia linked to type II diabetes disrupt ER homeostasis, thereby, resulting in irreversible UPR activation and cell death. Despite progress in understanding the pathophysiology of the UPR and ER stress, to date, the mechanisms of ER stress in relation to type II diabetes remain unclear. This review provides up-to-date information regarding the UPR, ER stress mechanisms, insulin dysfunction, oxidative stress, and the therapeutic potential of targeting specific ER stress pathways.

Item Type: Article
Funders: Malaysian Ministry of Higher Education [Grant No: 203/PPSP/6171215]
Uncontrolled Keywords: Endoplasmic reticulum; Endoplasmic reticulum stress; Apoptosis; Homeostasis; Unfolded protein response; Type II diabetes
Subjects: Q Science > QD Chemistry
R Medicine > R Medicine (General)
Divisions: Faculty of Medicine
Depositing User: Ms Zaharah Ramly
Date Deposited: 24 May 2022 08:43
Last Modified: 24 May 2022 08:43

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