A new antiplasmodial sterol from Indonesian marine sponge, Xestospongia sp

Murtihapsari and Salam, Supriatno and Kurnia, Dikdik and Darwati and Kadarusman and Abdullah, Fajar Fauzi and Herlina, Tati and Husna, Muhammad Hafiz and Awang, Khalijah and Shiono, Yoshihito and Azmi, Mohamad Nurul and Supratman, Unang (2021) A new antiplasmodial sterol from Indonesian marine sponge, Xestospongia sp. Natural Product Research, 35 (6). pp. 937-944. ISSN 1478-6419, DOI https://doi.org/10.1080/14786419.2019.1611815.

Full text not available from this repository.


A new antimalarial sterol, kaimanol (1), along with a known sterol, saringosterol (2) was isolated from the Indonesian Marine sponge, Xestospongia sp. The chemical structure of the new compound was determined on the basis of spectroscopic evidences and by comparison to those related compounds previously reported. Isolated compounds, 1 and 2 were evaluated for their antiplasmodial effect against Plasmodium falciparum 3D7 strains. Compounds 1 and 2 exhibited antiplasmodial activity with IC50 values of 359 and 0.250 nM, respectively. GRAPHICS] .

Item Type: Article
Funders: BPPDN, Ministry of Research and Technology of the Republic of Indonesia (RISTEK)
Uncontrolled Keywords: Xestospongia sp;Sterol;Kaimanol;Plasmodium falcifarum; Petrosiidae
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science
Depositing User: Ms Zaharah Ramly
Date Deposited: 15 Sep 2022 01:36
Last Modified: 15 Sep 2022 01:36
URI: http://eprints.um.edu.my/id/eprint/34542

Actions (login required)

View Item View Item