Evaluation of immature platelet fraction as a marker of dengue fever progression

Looi, Kah Wai and Matsui, Yukari and Kono, Mari and Samudi, Chandramathi and Kojima, Nozomi and Ong, Jin Xu and Tan, Chin Aun and Ang, Chong Siang and Tan, Peter Hao Yuan and Shamnugam, Hemalatha and Sekaran, Shamala Devi and Omar, Sharifah Faridah Syed and Lum, Lucy Chai See (2021) Evaluation of immature platelet fraction as a marker of dengue fever progression. International Journal of Infectious Diseases, 110. pp. 187-194. ISSN 1201-9712, DOI https://doi.org/10.1016/j.ijid.2021.07.048.

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Objectives: Progression of dengue is often associated with thrombocytopenia resulting from viral-induced bone marrow suppression and immune-mediated peripheral platelet consumption. Immature platelet fraction (IPF), which can be measured using a haematology analyser, is a precursor indicating platelet formation in the bone marrow. This study evaluated the trend of IPF as an early recovery indicator of platelets in dengue patients with thrombocytopenia, and its relationship with severe dengue in conjunction with reticulocyte count. Methods: Hospitalized patients with dengue were enrolled and followed-up daily until discharge. Blood investigations included daily full blood counts and IPF measured using a haematology analyser. Results: In total, 287 patients with confirmed dengue were enrolled in this study, 25 of whom had severe dengue. All patients had a decreasing trend in platelet count in the first week of illness, concomitant with an increasing trend in the percentage of immature platelets to total platelets (IPF%) for more than 3 days prior to platelet recovery. IPF% was significantly increased in patients with severe dengue compared with patients with non-severe dengue on days 3-5 after the onset of fever. Reticulocyte count increased significantly in patients with severe dengue on day 5. Conclusions: IPF can be utilized as an early recovery indicator of platelets in patients with dengue and thrombocytopenia. (c) 2021 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)

Item Type: Article
Funders: Sysmex Corporation
Uncontrolled Keywords: Dengue fever; Platelet; Immature platelet fraction; Disease progression; Platelet recovery
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine
Depositing User: Ms Zaharah Ramly
Date Deposited: 01 Jun 2022 06:54
Last Modified: 01 Jun 2022 06:54
URI: http://eprints.um.edu.my/id/eprint/34534

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