Finding a balance in the vaginal microbiome: How do we treat and prevent the occurrence of bacterial vaginosis?

Joseph, Rebecca Jane and Ser, Hooi-Leng and Kuai, Yi-He and Tan, Loh Teng-Hern and Arasoo, Valliammai Jayanthi Thirunavuk and Letchumanan, Vengadesh and Wang, Lijing and Pusparajah, Priyia and Goh, Bey-Hing and Ab Mutalib, Nurul-Syakima and Chan, Kok-Gan and Lee, Learn-Han (2021) Finding a balance in the vaginal microbiome: How do we treat and prevent the occurrence of bacterial vaginosis? Antibiotics-Basel, 10 (6). ISSN 2079-6382, DOI

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Bacterial vaginosis (BV) has been reported in one-third of women worldwide at different life stages, due to the complex balance in the ecology of the vaginal microbiota. It is a common cause of abnormal vaginal discharge and is associated with other health issues. Since the first description of anaerobic microbes associated with BV like Gardnerella vaginalis in the 1950s, researchers have stepped up the game by incorporating advanced molecular tools to monitor and evaluate the extent of dysbiosis within the vaginal microbiome, particularly on how specific microbial population changes compared to a healthy state. Moreover, treatment failure and BV recurrence rate remain high despite the standard antibiotic treatment. Consequently, researchers have been probing into alternative or adjunct treatments, including probiotics or even vaginal microbiota transplants, to ensure successful treatment outcomes and reduce the colonization by pathogenic microbes of the female reproductive tract. The current review summarizes the latest findings in probiotics use for BV and explores the potential of vaginal microbiota transplants in restoring vaginal health.

Item Type: Article
Funders: Jeffrey Cheah School of Medicine and Health Sciences (JCSMHS) [Grant No: SED-000068], Fundamental Research Grant Scheme [Grant No: FRGS/1/2019/SKK08/MUSM/02/7], Biomerge Sdn Bhd [Grant No: BMRG2018-01], University of Malaya Research Grant (FRGS) [Grant No: FP022-2018A]
Uncontrolled Keywords: Bacterial vaginosis; Microbiome; Probiotics; Lactobacillus; Gardnerella; VMT
Subjects: R Medicine > RS Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > Pharmacopoeia
Divisions: Faculty of Science > Institute of Biological Sciences
Depositing User: Ms Zaharah Ramly
Date Deposited: 30 May 2022 07:34
Last Modified: 30 May 2022 07:34

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