Recommendations by the Asian Pacific Society of Nephrology (APSN) on the appropriate use of HIF-PH inhibitors

Yap, Desmond Y. H. and McMahon, Lawrence P. and Hao, Chuan-Ming and Hu, Nan and Okada, Hirokazu and Suzuki, Yusuke and Kim, Sung Gyun and Lim, Soo Kun and Vareesangthip, Kriengsak and Hung, Chi-Chih and Nangaku, Masaomi and Comm, APSN HIF-PHI Recommendation (2021) Recommendations by the Asian Pacific Society of Nephrology (APSN) on the appropriate use of HIF-PH inhibitors. Nephrology, 26 (2). pp. 105-118. ISSN 1320-5358, DOI

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Renal anaemia is a common and important complication in patients with chronic kidney disease (CKD). The current standard-of-care treatment for renal anaemia in CKD patients involves ensuring adequate iron stores and administration of erythropoietin stimulating agents (ESA). Hypoxia inducible factor (HIF) is a key transcription factor primarily involved in the cellular regulation and efficiency of oxygen delivery. Manipulation of the HIF pathway by the use of HIF-prolyl hydroxylase inhibitors (HIF-PHI) has emerged as a novel approach for renal anaemia management. Despite it being approved for clinical use in various Asia-Pacific countries, its novelty mandates the need for nephrologists and clinicians generally in the region to well understand potential benefits and harms when prescribing this class of drug. The Asian Pacific society of nephrology HIF-PHI Recommendation Committee, formed by a panel of 11 nephrologists from the Asia-Pacific region who have clinical experience or have been investigators in HIF-PHI studies, reviewed and deliberated on the clinical and preclinical data concerning HIF-PHI. This recommendation summarizes the consensus views of the committee regarding the use of HIF-PHI, taking into account both available data and expert opinion in areas where evidence remains scarce.

Item Type: Article
Uncontrolled Keywords: Anaemia;Asian Pacific;Chronic kidney disease;Hypoxia inducible factor;Prolyl hydroxylase inhibitor
Subjects: R Medicine
R Medicine > RA Public aspects of medicine
R Medicine > RC Internal medicine
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Faculty of Medicine
Depositing User: Ms Zaharah Ramly
Date Deposited: 15 Sep 2022 05:10
Last Modified: 15 Sep 2022 05:10

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