Laser-heated needle for biopsy tract ablation: In vivo study of rabbit liver biopsy

Abd Raziff, Hani Hareiza and Tan, Daryl and Tan, Soon Hao and Wong, Yin How and Lim, Kok Sing and Yeong, Chai Hong and Sulaiman, Norshazriman and Abdullah, Basri Johan Jeet and Wali, Haryanti Azura Mohamad and Zailan, Nur Azmina Mohd and Ahmad, Harith (2021) Laser-heated needle for biopsy tract ablation: In vivo study of rabbit liver biopsy. Physica Medica-European Journal of Medical Physics, 82. pp. 40-45. ISSN 1120-1797, DOI

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To investigate the efficacy of a newly-developed laser-heated core biopsy needle in the thermal ablation of biopsy tract to reduce hemorrhage after biopsy using in vivo rabbit's liver model. Materials and methods: Five male New Zealand White rabbits weighed between 1.5 and 4.0 kg were anesthetized and their livers were exposed. 18 liver biopsies were performed under control group (without tract ablation, n 9) and study group (with tract ablation, n = 9) settings. The needle insertion depth (similar to 3 cm) and rate of retraction (similar to 3 mm/s) were fixed in all the experiments. For tract ablation, three different needle temperatures (100, 120 and 150 degrees C) were compared. The blood loss at each biopsy site was measured by weighing the gauze pads before and after blood absorption. The rabbits were euthanized immediately and the liver specimens were stained with hematoxylin-eosin (H&E) for further histopathological examination (HPE). Results: The average blood loss in the study group was reduced significantly (p < 0.05) compared to the control group. The highest percentage of bleeding reduction was observed at the needle temperature of 150 degrees C (93.8%), followed by 120 degrees C (85.8%) and 100 degrees C (84.2%). The HPE results show that the laser-heated core biopsy needle was able to cause lateral coagulative necrosis up to 14 mm diameter along the ablation tract. Conclusion: The laser-heated core biopsy needle reduced hemorrhage up to 93.8% and induced homogenous coagulative necrosis along the ablation tract in the rabbits' livers. This could potentially reduce the risk of tumor seeding in clinical settings.

Item Type: Article
Funders: Prototype Research Grant Scheme, Ministry of Education Malaysia[PRGS/1/2017/SKK03/UM/02/1], Taylor's University through the Taylor's Research Scholarship Programme
Uncontrolled Keywords: Biopsy;Tract ablation;Fiber laser;Hemorrhage;Coagulative necrosis;Rabbits
Subjects: Q Science > QC Physics
R Medicine
R Medicine > R Medicine (General)
R Medicine > R Medicine (General) > Medical technology
Divisions: Faculty of Medicine
Depositing User: Ms Zaharah Ramly
Date Deposited: 13 Sep 2022 07:01
Last Modified: 13 Sep 2022 07:01

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