Isolation of Streptococcus cuniculi from corneal lesion in laboratory-raised mice

Tiong, Vunjia and Loong, Shih-Keng and Wali, Haryanti Azura Mohamad and Tan, Kim-Kee and Jee, Pui-Fong and Lim, Fang-Shiang and Khoo, Jing-Jing and Wong, Pooi-Fong and Chang, Li-Yen and Abubakar, Sazaly (2021) Isolation of Streptococcus cuniculi from corneal lesion in laboratory-raised mice. Journal of Veterinary Medical Science, 83 (2). pp. 280-284. ISSN 0916-7250, DOI

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Corneal lesions appearing as white mass beneath intact epithelium, with ocular discharge in one mouse, was observed in a batch of laboratory-raised BALB/c mice (n=9 of 56). The affected mice remained active, well-groomed and had normal appetite. Isolates recovered from swab cultures of the external and internal contents of the eye had partial 16S rRNA gene sequence of 99.1% similarity to Streptococcus cuniculi. No previous report of S. cuniculi infection in laboratory rodents has been presented. The isolate was susceptible to all antibiotics tested. We suggest S. cuniculi is an opportunistic bacteria in laboratory mice but are uncertain of its source. Our findings revealed that S. cuniculi is able to colonize laboratory mice and should be considered when mice present with eye lesion or ocular discharge.

Item Type: Article
Funders: Universiti Malaya[RU002-2019], Universiti Malaya[RU005-2020], UMCoE Top 100 Research Grant[UM.00000188/HGA.GV], Pharmaceutical & Nutraceutical R&D Initiatives Fund[09-05-IFN-MEB-005]
Uncontrolled Keywords: Eye;Infectious disease;Laboratory mouse;Streptococcus cuniculi
Subjects: Q Science > QR Microbiology
R Medicine
R Medicine > RB Pathology > Theories of disease. Etiology. Pathogenesis
Divisions: Deputy Vice Chancellor (Research & Innovation) Office > Tropical Infectious Diseases Research and Education Centre
Depositing User: Ms Zaharah Ramly
Date Deposited: 13 Sep 2022 04:24
Last Modified: 13 Sep 2022 04:25

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