Neural fiber integrity in high-versus low-grade glioma using probabilistic fiber tracking

Seow, Pohchoo and Hernowo, Aditya T. and Narayanan, Vairavan and Wong, Jeannie Hsiu Ding and Bahuri, Nor Faizal Ahmad and Cham, Chun Yoong and Abdullah, Nor Aniza and Kadir, Khairul Azmi Abdul and Rahmat, Kartini and Ramli, Norlisah (2021) Neural fiber integrity in high-versus low-grade glioma using probabilistic fiber tracking. Academic Radiology, 28 (12). pp. 1721-1732. ISSN 1076-6332, DOI

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Rationale and Objectives: Gliomatous tumors are known to affect neural fiber integrity, either by displacement or destruction. The aim of this study is to investigate the integrity and distribution of the white matter tracts within and around the glioma regions using probabilistic fiber tracking. Material and Methods: Forty-two glioma patients were subjected to MRI using a standard tumor protocol with diffusion tensor imaging (DTI). The tumor and peritumor regions were delineated using snake model with reference to structural and diffusion MRI. A preprocessing pipeline of the structural MRI image, DTI data, and tumor regions was implemented. Tractography was performed to delineate the white matter (WM) tracts in the selected tumor regions via probabilistic fiber tracking. DTI indices were investigated through comparative mapping of WM tracts and tumor regions in low-grade gliomas (LGG) and high-grade gliomas (HGG). Results: Significant differences were seen in the planar tensor (C-p) in peritumor regions; mean diffusivity, axial diffusivity and pure isotropic diffusion in solid-enhancing tumor regions; and fractional anisotropy, axial diffusivity, pure anisotropic diffusion (q), total magnitude of diffusion tensor (L), relative anisotropy, C-p and spherical tensor (C-s) in solid nonenhancing tumor regions for affected WM tracts. In most cases of HGG, the WM tracts were not completely destroyed, but found intact inside the tumor. Discussion: Probabilistic fiber tracking revealed the existence and distribution of WM tracts inside tumor core for both LGG and HGG groups. There were more DTI indices in the solid nonenhancing tumor region, which showed significant differences between LGG and HGG.

Item Type: Article
Funders: University Malaya Fundamental Research Grant Scheme[FP009-2016], University Malaya Fundamental Research Grant Scheme[University Malaya Fundamental Research Grant Scheme FP009-2016 FP0182019A]
Uncontrolled Keywords: Probabilistic fiber tracking;DTI;Glioma;White matter tracts; Infiltration
Subjects: R Medicine
R Medicine > R Medicine (General)
R Medicine > R Medicine (General) > Medical technology
Divisions: Faculty of Medicine
Depositing User: Ms Zaharah Ramly
Date Deposited: 13 Sep 2022 07:36
Last Modified: 13 Sep 2022 07:36

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