The effect of a single session of 30-min mindful breathing in reducing fatigue among patients with haematological cancer :A randomised controlled trial

Ng, Diana-Leh-Ching and Gan, Gin-Gin and Anuar, Nur Adila and Tung, Yu-Zhen and Lai, Natalie-Zi and Tan, Yi-Wen and Said, Siti Norazilah Mohd and Madihie, Amalia and Chai, Chee-Shee and Tan, Seng-Beng (2021) The effect of a single session of 30-min mindful breathing in reducing fatigue among patients with haematological cancer :A randomised controlled trial. BMC Palliative Care, 20 (1). ISSN 1472-684X, DOI

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Patients with haematological cancer had considerable symptom burden, in which fatigue was the most prevalent. Almost 70% of haematological cancer patients reported fatigue. Methods: We conducted a parallel-group, non-blinded, randomised control trial at the haemato-oncology unit of University Malaya Medical Centre, from 1st October 2019 to 31st May 2020. Patients included were >= 18 years, had histopathological diagnosis of haematological cancer, and fatigue score of >= 4 based on the fatigue subscale of Edmonton Symptom Assessment System (ESAS). Patients allocated to the intervention group received standard care plus a guided 30-min mindful breathing session, while those in control group received standard care. The study outcomes include fatigue severity according to the fatigue subscale of ESAS, visual analogue scale of 0 - 10, and Functional Assessment of Chronic Illness Therapy Fatigue Scale Version 4, at minute 0 and minute 30. Results: Of 197 patients screened, 80 were eligible and they were equally randomised into 30-min mindful breathing versus standard care. Lymphoma (58.9%) was the commonest haematological malignancy, followed by multiple myeloma (13.8%), acute leukaemia (11.3%), myeloproliferative neoplasm (6.3%), chronic leukaemia (5.0%) and myelodysplastic syndrome (5.0%). There was no difference in the demographic and clinical characteristics between the 2 groups. At minute 0, both arms of patients had similar ESAS-fatigue score (median, 5) and FACIT-fatigue score (mean +/- SD, 24.7 +/- 10.6 for intervention group versus 24.7 +/- 9.7 for control group). At minute 30, intervention group had lower ESAS-fatigue score (median, 3 versus 5) and FACIT-fatigue score (mean +/- SD, 17.1 +/- 10.5 versus 24.8 +/- 11.3) compared to control group. Both the ESAS-fatigue score reduction (median, - 2 versus 0, p = 0.002) and FACIT-fatigue score reduction (mean +/- SD, - 6.7 versus + 0.8; p < 0.001) for the intervention group were statistically significant. The calculated effect size Cohen's d was 1.4 for between-group comparison of differences in total FACIT-fatigue score. Conclusions: Our results provide evidence that a single session of 30-min mindful breathing was effective in reducing fatigue in haematological cancer patients. On top of all the currently available methods, 30-min mindful breathing can prove a valuable addition.

Item Type: Article
Funders: UNIMAS Cross Discipline Research Grant[F05/CDRG/1844/2019], Universiti Malaysia Sarawak
Uncontrolled Keywords: Haematological cancer;Fatigue;Mindful breathing;Edmonton symptom assessment system;Functional assessment of chronic illness therapy fatigue scale
Subjects: R Medicine
R Medicine > RA Public aspects of medicine
R Medicine > RC Internal medicine
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculty of Medicine
Depositing User: Ms Zaharah Ramly
Date Deposited: 13 Sep 2022 02:37
Last Modified: 13 Sep 2022 02:37

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