A review of ethnobotany, phytochemistry, antimicrobial pharmacology and toxicology of Nigella sativa L.

Hossain, Md. Sanower and Sharfaraz, Ashik and Dutta, Amit and Ahsan, Asif and Masud, Md. Anwarul and Ahmed, Idris Adewale and Goh, Bey Hing and Urbi, Zannat and Sarker, Md. Moklesur Rahman and Ming, Long Chiau (2021) A review of ethnobotany, phytochemistry, antimicrobial pharmacology and toxicology of Nigella sativa L. Biomedicine & Pharmacotherapy, 143. ISSN 0753-3322, DOI https://doi.org/10.1016/j.biopha.2021.112182.

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Nigella sativa L. is one of the most extensively used traditional medicinal plants. This widely studied plant is known to display diverse pharmacological actions, including antimicrobial activities. Current literature has documented its multi-target mode of antimicrobial actions. N. sativa or its bioactive compounds, such as thymoquinone, can induce oxidative stress, cell apoptosis (by producing reactive oxygen species), increase membrane permeability, inhibit efflux pumps, and impose strong biocidal actions. Despite its well-documented antimicrobial efficacy in the experimental model, to the best of our knowledge its antimicrobial mechanisms highlighting the multi-targeting properties have yet to be well discussed. Is N. sativa or thymoquinone a valuable lead compound for therapeutic development for infectious diseases? Are N. sativa's bioactive compounds potential antimicrobial agents or able to overcome antimicrobial resistance? This review aims to discuss the antimicrobial pharmacology of N. sativa-based treatments. Additionally, it provides a holistic overview of the ethnobotany, ethnopharmacology, and phytochemistry of N. sativa.

Item Type: Article
Uncontrolled Keywords: Antibacterial agent;Antibiotic resistance;Bioactive molecules;Medicinal plant;Natural products; PhytochemistryToxicology
Subjects: Q Science > QR Microbiology
R Medicine
R Medicine > RS Pharmacy and materia medica
R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Divisions: Centre for Natural Products Research and Drug Discovery (CENAR)
Depositing User: Ms Zaharah Ramly
Date Deposited: 13 Sep 2022 01:38
Last Modified: 13 Sep 2022 01:38
URI: http://eprints.um.edu.my/id/eprint/34348

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