Tri-metallic Co-Ni-Cu based metal organic framework nanostructures for the detection of an anticancer drug nilutamide

Akhter, Shamima and Zain, Nurul Khairiyyah Mohd and Shalauddin, Md and Singh, Vivek Kumar and Misnon, Izan Izwan and Sharma, Rajendra Kumar and Das, Santanu and Basirun, Wan Jeffrey and Johan, Mohd Rafie and Jose, Rajan (2021) Tri-metallic Co-Ni-Cu based metal organic framework nanostructures for the detection of an anticancer drug nilutamide. Sensors and Actuators A-Physical, 325. ISSN 0924-4247, DOI

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This work reports a biosensor based on tri-metallic organic framework (MOF) for the determination of an anticancer therapeutic agent, nilutamide (NLM). The tri-metallic Co-Ni-Cu-MOF and the single metal MOFs Co-MOF, Ni-MOF and Cu-MOF were grown onto nickel foam (NF) substrate by a solvothermal method. The crystal, chemical structure, morphology and surface area of the MOFs were studied by X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), field emission scanning electron microscopy (FESEM), energy dispersive X-ray (EDX) transmission electron microscopy (TEM) and Brunauer-Emmett-Teller (BET) analysis. The electrochemical sensing of NLM by the Co-Ni-Cu-MOF/NF and the single metal MOFs grown onto NF were studied by cyclic voltammetry (CV), differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS). The CV of the Co-Ni-Cu-MOF/NF shows a redox couple between-0.4 V and 0.3 V in phosphate buffer solution at pH 7.0. The Co-Ni-Cu-MOF/NF sensor shows a strong electrocatalytic activity towards the redox reaction of NLM with a broad concentration range from 0.5-70 mu M and 70-900 mu M with high sensitivity of 10.712 mu A mu M-1 cm(-2) and a low limit of detection of 0.48 +/- 0.02 nM. These results confirm that the tri-metallic MOF possesses high selectivity and sensitivity for the determination of NLM from human serum specimen and pharmaceutical tablet dosage forms. (C) 2021 Elsevier B.V. All rights reserved.

Item Type: Article
Funders: Universiti Malaya, University Malaysia Pahang[PG226-2015A], University Malaysia Pahang[PGRS170394], Ministry of Higher Education (MOHE) Malaysia[RU2020], Ministry of Higher Education (MOHE) Malaysia[RH 2017], Ministry of Higher Education (MOHE) Malaysia[RDU190142], STAR Project Ministry of Human Resource and Development, Govt. of India[STARS/APR2019/NS/428/FS]
Uncontrolled Keywords: Tri-metallic Co-Ni-Cu-MOF/NF;Biosensor;Nilutamide; Differential pulse voltammetry;Cyclic voltammetry;Real samples
Subjects: Q Science > QC Physics
Q Science > QD Chemistry
Divisions: Faculty of Science
Depositing User: Ms Zaharah Ramly
Date Deposited: 12 Sep 2022 03:00
Last Modified: 12 Sep 2022 03:00

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