A national audit of estimated glomerular filtration rate and proteinuria and the MACB CKD Task Force recommendations

Sthaneshwar, Pavai and Lai, Leslie Charles and Raja Azzidin, Raja Elina and Mohd Hussain, Baizurah and Anas, Siti Sharina and Supremaniam, Sivasangkari and Lee, Low Yoke and Mohamad Noor, Nafisah and Harun, Harmiza Bte (2021) A national audit of estimated glomerular filtration rate and proteinuria and the MACB CKD Task Force recommendations. Malaysian Journal of Pathology, 43 (1). pp. 41-48. ISSN 0126-8635,

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The Malaysian Association of Clinical Biochemists (MACB) established a Task Force for Chronic Kidney Disease. A survey was undertaken by the Task Force on the reporting of estimated glomerular filtration rate (eGFR) and urine albumin by hospital laboratories in Malaysia in both the government and private sectors. Materials and Methods: An e-mail invitation to participate in an online survey was sent to hospital laboratories in Malaysia (n=140). Questions regarding methods for measuring creatinine, equations for calculating eGFR, eGFR reporting, the terminology used in reporting urine albumin, types of samples and the cut-off values used for normal albuminuria. Results: A total of 42/140 (30%) laboratories answered the questionnaire. The prevalent method used for serum creatinine measurement was the Jaffe method (88.1%) traceable to isotope-dilution mass spectrometry. eGFR was reported along with serum creatinine by 61.9% of laboratories while 33.3% of laboratories report eGFR on request. The formula used for eGFR reporting was mainly MDRD (64.3%) and results were reported as exact numbers even when the eGFR was >60 ml/min/1.73m(2). The term microalbumin is still used by 83.3% of laboratories. There is a large heterogeneity among the labs regarding the type of sample recommended for measuring urine albumin, reference interval and reporting units. Conclusion: It is evident that the laboratory assessment of chronic kidney disease in Malaysia is not standardised. It is essential to provide a national framework for standardised reporting of eGFR and urine albumin. Recommendations developed by the MACB CKD Task Force, if adopted by all laboratories, will lead to a reduction in this variability.

Item Type: Article
Uncontrolled Keywords: CKD;eGFR;Urine albumin
Subjects: R Medicine
R Medicine > RB Pathology
Divisions: Faculty of Medicine
Depositing User: Ms Zaharah Ramly
Date Deposited: 09 Sep 2022 02:24
Last Modified: 09 Sep 2022 02:24
URI: http://eprints.um.edu.my/id/eprint/34276

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