Survey on serum protein electrophoresis and recommendations for standardised reporting

Sthaneshwar, Pavai and Thambiah, C. Subashini and Salleh, Mohd Jamsani Mat and Nasuruddin, Dian Nasriana and Zabidi, Nurul Faatima Ahmad and Jelani, Aniza Mohammed and Ismail, Aletza Mohd and Lai, Leslie Charles and Gan, Gin Gin (2021) Survey on serum protein electrophoresis and recommendations for standardised reporting. Malaysian Journal of Pathology, 43 (2). pp. 281-290. ISSN 0126-8635,

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Serum protein electrophoresis (SPE) is a well-established laboratory technique. However, reporting of results varies considerably between laboratories. The variation in reporting can cause confusion to the clinician with a potential of adversely impacting patient care. The purpose of the survey was to find out the variation in reporting and to prepare recommendations to the Malaysian laboratories based on the survey to reduce both the variation in reporting between laboratories and the risk of misinterpretation of reports. Materials and Methods: To determine the extent of variation in reporting of protein electrophoresis results questionnaires were distributed to the pathologists of various laboratories in Malaysia regarding the method, quantification of paraprotein concentrations and immunoglobulin assays, and information regarding current laboratory electrophoresis practices. Results: Variation was found in the following reporting practices: (a) screening protocol; (b) reporting of serum albumin; (c) numerical reporting of protein fractions and paraprotein; (d) co-migration of a paraprotein with a normal serum protein; (e) reporting of multiple paraprotein bands (1) appearance of small abnormal band and oligoclonal bands and (g) communication about of interferences. Conclusion: The pathologists of the country made recommendations on the reporting of protein electrophoresis. Harmonised reporting will reduce inconsistency, variation in reporting, improve the quality of the report and most importantly improve patient care.

Item Type: Article
Uncontrolled Keywords: Multiple myeloma;Protein electrophoresis;Standardised reporting
Subjects: R Medicine
R Medicine > RB Pathology
Divisions: Faculty of Medicine
Depositing User: Ms Zaharah Ramly
Date Deposited: 09 Sep 2022 02:31
Last Modified: 09 Sep 2022 02:31

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