Facile in-situ fabrication of a ternary ZnO/TiO2/Ag nanocomposite for enhanced bactericidal and biocompatibility properties

Sakthi Mohan, Priyadarshini and Sonsuddin, Faridah and Mainal, Azizah and Yahya, Rosiyah and Venkatraman, Gopinath and S. Vadivelu, Jamuna and Al-Farraj, Dunia A. and Al-Mohaimeed, Amal M. and Alarijani, Khaloud Mohammed (2021) Facile in-situ fabrication of a ternary ZnO/TiO2/Ag nanocomposite for enhanced bactericidal and biocompatibility properties. Antibiotics-Basel, 10 (1). ISSN 2079-6382, DOI https://doi.org/10.3390/antibiotics10010086.

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This paper presents for the first time a successful fabrication of ternary ZnO/TiO2/Ag nanocomposites consisting of zinc oxide (ZnO), titania (TiO2) and silver (Ag) nanoparticles (NPs) synthesised using Morinda citrifolia fruit (MCF) extract. ZnONPs were synthesised using the co-precipitation method, and TiO2 and Ag were introduced into the precursor solutions under microwave irradiation to obtain ZnO/TiO2/Ag nanocomposites (NCs). This material demonstrated enhanced bactericidal effect towards bacterial pathogens compared to that of the binary TiO2/Ag, Ag and TiO2 alone. In vitro cytotoxicity results of the as-synthesised ZnO/TiO2/AgNCs on RAW 264.7 macrophages and A549 cell lines revealed a negative role in cytotoxicity, but contributed astoundingly towards antimicrobials as compared of Ag alone and binary Ag/TiO2. This study shows that the resultant ternary metal/bi-semiconductor nanocomposites may provide a therapeutic strategy for the eradication of bacterial pathogens without affecting the healthy mammalian cells.

Item Type: Article
Funders: University of Malaya-Ministry of Education, Malaysia [IIRG019B-2019], King Saud University [RSP-2020/185]
Uncontrolled Keywords: Antibacterial; Semiconductor materials; Nanocomposites; Precipitation; Cytotoxicity
Subjects: R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
R Medicine > RC Internal medicine
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Divisions: Centre for Foundation Studies in Science > Chemistry Division
Faculty of Medicine
Faculty of Science > Department of Chemistry
Depositing User: Ms Zaharah Ramly
Date Deposited: 13 Jun 2022 01:48
Last Modified: 13 Jun 2022 01:48
URI: http://eprints.um.edu.my/id/eprint/34265

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