In vivo hepatoprotective effect of Morinda elliptica stem extract against liver fibrosis induced by thioacetamide

Bradosty, Sarwan W. and Hamad, Saber W. and Agha, Nabaz Fisal Shakir and Shaikh, Faiyaz Khudaboddin and Qadir Nanakali, Nadir Mustafa and Aziz, Peshawa Yunis and Salehen, Nur'Ain and Suzergoz, Faruk and Abdulla, Mahmood Ameen (2021) In vivo hepatoprotective effect of Morinda elliptica stem extract against liver fibrosis induced by thioacetamide. Environmental Toxicology, 36 (12). pp. 2404-2413. ISSN 1520-4081, DOI

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Morinda elliptica L. (Rubiaceae) is a phytomedicinal herb, used to treat gastrointestinal complications in Peninsular Malaysia. The study evaluates the in vivo hepatoprotective activity of ethanolic extract of M. elliptica stem in thioacetamide (TAA) induced liver fibrosis in male Sprague Drawly rats. Thirty adult rats were divided into five groups of six rats each. Rats of the normal control group received intraperitoneal injections (i. p.) of vehicle 10% Tween-20, 5 ml/kg, and hepatotoxic group 200 mg/kg TAA three times per week respectively. Three supplementary groups were treated with TAA plus daily oral silymarin (50 mg/kg) or M. elliptica (250 or 500 mg/kg). After 8 weeks of treatment, all rats were sacrificed. Liver fibrosis was assessed by gross macroscopic and microscopic tissue analysis, histopathological, and biochemical analysis. The livers of the TAA treated group showed uniform coarse granules, hepatocytic necrosis with lymphocytes infiltration. Contrary, the livers of M. elliptica treated groups (250 and 500 mg/kg) were much smoother and the cell damage was much lesser. The livers of M. elliptica treated groups rats showed elevated activity of SOD and CAT with a significant decrease in MDA level at p < .0001. The level of liver damage parameters, that is, ALP, ALT, and AST, bilirubin, total protein, and albumin were restored to the normal comparable to silymarin. M. elliptica stem extract significantly promoted normal rat liver architecture with significant perfections in biochemical parameters. The molecular contents of M. elliptica with hepatoprotective influence could be discovered, is the future prospective of this study.

Item Type: Article
Funders: University of Malaya High Impact Grant[E000045-20001]
Uncontrolled Keywords: Antioxidant enzymes;Hepatoprotective;Liver biomarkers; Morinda elliptica;Thioacetamide
Subjects: G Geography. Anthropology. Recreation > GE Environmental Sciences
Q Science > Q Science (General)
Divisions: Faculty of Medicine
Depositing User: Ms Zaharah Ramly
Date Deposited: 20 Jun 2022 06:47
Last Modified: 20 Jun 2022 06:47

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