The extremophilic actinobacteria: From microbes to medicine

Hui, Martha Lok-Yung and Tan, Loh Teng-Hern and Letchumanan, Vengadesh and He, Ya-Wen and Fang, Chee-Mun and Chan, Kok-Gan and Law, Jodi Woan-Fei and Lee, Learn-Han (2021) The extremophilic actinobacteria: From microbes to medicine. Antibiotics-Basel, 10 (6). ISSN 2079-6382, DOI

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Actinobacteria constitute prolific sources of novel and vital bioactive metabolites for pharmaceutical utilization. In recent years, research has focused on exploring actinobacteria that thrive in extreme conditions to unearth their beneficial bioactive compounds for natural product drug discovery. Natural products have a significant role in resolving public health issues such as antibiotic resistance and cancer. The breakthrough of new technologies has overcome the difficulties in sampling and culturing extremophiles, leading to the outpouring of more studies on actinobacteria from extreme environments. This review focuses on the diversity and bioactive potentials/medically relevant biomolecules of extremophilic actinobacteria found from various unique and extreme niches. Actinobacteria possess an excellent capability to produce various enzymes and secondary metabolites to combat harsh conditions. In particular, a few strains have displayed substantial antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA), shedding light on the development of MRSA-sensitive antibiotics. Several strains exhibited other prominent bioactivities such as antifungal, anti-HIV, anticancer, and anti-inflammation. By providing an overview of the recently found extremophilic actinobacteria and their important metabolites, we hope to enhance the understanding of their potential for the medical world.

Item Type: Article
Funders: SEED Funding from Microbiome and Bioresource Research Strength (MBRS), Jeffrey Cheah School of Medicine and Health Sciences [Grant No: MBRS/JCSMHS/02/2020], JCSMHS [Grant No: STG-000051], University of Malaya Research Grant (FRGS grant) [Grant No: FP022-2018A], Fundamental Research Grant Scheme [Grant No: FRGS/1/2019/SKK08/MUSM/02/7]
Uncontrolled Keywords: Extremophile; Actinobacteria; Environment; Bioactivity; Metabolites
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Science > Institute of Biological Sciences
Depositing User: Ms Zaharah Ramly
Date Deposited: 17 Jun 2022 08:14
Last Modified: 17 Jun 2022 08:14

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