Cytotoxic constituent of Melicope latifolia (DC.) T. G. Hartley

Lim, Pei Cee and Ali, Zulfiqar and Khan, Ikhlas A. and Khan, Shabana and Kassim, Nur Kartinee and Awang, Khalijah and Shaari, Khozirah and Ismail, Amin (2022) Cytotoxic constituent of Melicope latifolia (DC.) T. G. Hartley. Natural Product Research, 36 (6). pp. 1416-1424. ISSN 1478-6419, DOI

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An undescribed conjugated sesquiterpene, amelicarin (1), together with nine known compounds (2-10) were isolated for the first time from Melicope latifolia. Their structures were elucidated by extensive NMR spectroscopic and mass spectrometric methods. The conjugated sesquiterpene possesses a unique 6/6/9/4-ring fused tetracyclic skeleton. The proposed biosynthesis pathway of 1 consist of three reactions steps: (1) polyketide formation, (2) cyclisation and (3) addition to form the conjugated sesquiterpenoid as final metabolite. Out of the ten isolated metabolites, amelicarin (1) showed activity against 4 cancerous cell lines namely SK-MEL skin cancer, KB oral cancer, BT-549 breast cancer, and SK-OV-3 ovarian cancer with IC50 values between 15 and 25 mu g/mL.

Item Type: Article
Funders: Universiti Putra Malaysia [GP-IPS 9618900]
Uncontrolled Keywords: Melicope latifolia; Rutaceae; Conjugated sesquiterpene; isolation; Cytotoxicity
Subjects: Q Science > QD Chemistry
R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Science > Department of Chemistry
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 25 Apr 2022 01:43
Last Modified: 25 Apr 2022 01:43

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