Decision-making for Risk-reducing Salpingo-oophorectomy (RRSO) in Southeast Asian BRCA Mutation Carriers With Breast Cancer: A Qualitative Study

Sa'at, Hamizah and Lee, Yew-Kong and Yoon, Sook-Yee and Wong, Siu Wan and Woo, Yin Ling and Barlow-Stewart, Kristine and Mohd Taib, Nur Aishah (2022) Decision-making for Risk-reducing Salpingo-oophorectomy (RRSO) in Southeast Asian BRCA Mutation Carriers With Breast Cancer: A Qualitative Study. International Journal of Behavioral Medicine, 29 (1). pp. 1-13. ISSN 1070-5503, DOI

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Background The uptake of risk-reducing salpingo-oophorectomy (RRSO) in Asian countries is variable despite being the most effective option for ovarian cancer risk reduction in BRCA mutation carriers. Exploration of factors which may impact the RRSO decision-making of BRCA mutation carriers from Malaysia, a developing country in Southeast Asia, was undertaken. Methods In-depth interviews with 28 Malaysian BRCA mutation carriers with a history of breast cancer were conducted in addition to observing their RRSO decision-making consultations in the clinic. Results The decision-making considerations among the carriers were centered around the overarching theme of ``Negotiating cancer risk and womanhood priorities,'' with the following themes: (1) risk perception, (2) self-preservation, (3) motherhood obligation, and (4) the preciousness of marriage. Cognitive knowledge of BRCA risk was often conceptualized based on personal and family history of cancer, personal beliefs, and faith. Many women reported fears that RRSO would affect them physically and emotionally, worrying about the post-surgical impact on their motherhood responsibilities. Nevertheless, some reported feeling obliged to choose RRSO for the sake of their children. For some, their husband's support and approval were critical, with emotional well-being and sexuality reportedly perceived as important to sustaining married life. Despite reporting hesitancy toward RRSO, women's decisions about choosing this option evolved as their priorities changed at different stages of life. Conclusions Recognizing during clinic encounters with Malaysian women that RRSO decision-making involves negotiating the likelihood of developing cancer with the societal priorities of being a woman, mother, and wife may serve to support their decision-making.

Item Type: Article
Funders: Terry Fox Run-Cancer Research Malaysia Research Grant, University Malaya Postgraduate Research grant (PPP) [PG075-2016A], High Impact Research Grant from the Ministry of Higher Education Malaysia [UM.C/HIR/MOHE/06]
Uncontrolled Keywords: BRCA1; BRCA2; Risk-reducing salpingo-oophorectomy; Ovarian cancer; Women’ S health
Subjects: R Medicine > R Medicine (General)
R Medicine > RZ Other systems of medicine > Mental healin
Divisions: Faculty of Medicine > Obstetrics & Gynaecology Department
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 25 Apr 2022 05:01
Last Modified: 25 Apr 2022 05:01

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