Walsogynes H-O from Walsura chrysogyne

Nugroho, Alfarius Eko and Nakajima, Saori and Wong, Chin Piow and Hirasawa, Yusuke and Kaneda, Toshio and Shirota, Osamu and Tougan, Takahiro and Horii, Toshihiro and Hadi, A. Hamid A. and Morita, Hiroshi (2022) Walsogynes H-O from Walsura chrysogyne. Journal of Natural Medicines, 76 (1). pp. 94-101. ISSN 1340-3443, DOI https://doi.org/10.1007/s11418-021-01556-4.

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Eight new limonoids, walsogynes H-O (1-8) were isolated from the barks of Walsura chrysogyne, and their structures were determined on the basis of the 1D and 2D NMR data. Walsogynes H-M (1-6) and O (8) were concluded to be 11,12-seco limonoids with a dodecahydro-1H-naphtho1,8-bc:3,4-c']difuran skeleton, and walsogyne N (7) to be 11,12-seco limonoid sharing a unique dodecahydronaphtho1,8-bc:5,4-b'c']difuran skeleton. Walsogynes H-O (1-8) exhibited potent antimalarial activity against Plasmodium falciparum 3D7 strain with IC50 value of 2.5, 2.6, 1.6, 2.5, 1.5, 2.6, 2.1, and 1.1 mu M, respectively.

Item Type: Article
Funders: Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research (KAKENHI) [Grant No: JP 19K07152 & JP 16K08309]
Uncontrolled Keywords: Limonoids; Walsura chrysogyne; Antimalarial activity
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Science > Department of Chemistry
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 25 Apr 2022 07:03
Last Modified: 25 Apr 2022 07:03
URI: http://eprints.um.edu.my/id/eprint/33802

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