Multifunctional applications of natural polysaccharide starch and cellulose: An update on recent advances

Gopinath, V and Kamath, S. Manjunath and Priyadarshini, S. and Chik, Zamri and Alarfaj, Abdullah A. and Hirad, Abdurahman H. (2022) Multifunctional applications of natural polysaccharide starch and cellulose: An update on recent advances. Biomedicine & Pharmacotherapy, 146. ISSN 0753-3322, DOI (In Press)

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The emergence of clinical complications and therapeutic challenges for treating various diseases necessitate the discovery of novel restorative functional materials. Polymer-based drug delivery systems have been extensively reported in the last two decades. Recently, there has been an increasing interest in the progression of natural biopolymers based controlled therapeutic strategies, especially in drug delivery and tissue engineering applications. However, the solubility and functionalisation due to their complex network structure and intramolecular bonding seem challenging. This review explores the current advancement and prospects of the most promising natural polymers such as cellulose, starch and their derivatives-based drug delivery vehicles like hydrogels, films and composites, in combating major ailments such as bone infections, microbial infections, and cancers. In addition, selective drug targeting using metal-drug (MD) and MD-based polymeric missiles have been exciting but challenging for its application in cancer therapeutics. Owing to high biocompatibility of starch and cellulose, these materials have been extensively evaluated in biomedical and pharmaceutical applications. This review presents a detailed impression of the current trends for the construction of biopolymer-based tissue engineering, drug/gene/protein delivery vehicles.

Item Type: Article
Funders: King Saud University [Grant No: RG-1435-065]
Uncontrolled Keywords: Cellulose; Starch; Cross-linking; Anticancer; Drug delivery; Antimicrobials; Wound healing
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Medicine
Faculty of Science
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 21 Jul 2022 02:27
Last Modified: 21 Jul 2022 02:27

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