Recent developments in metabolomics studies of endophytic fungi

Nagarajan, Kashvintha and Ibrahim, Baharudin and Ahmad Bawadikji, Abdulkader and Lim, Jun-Wei and Tong, Woei-Yenn and Leong, Chean-Ring and Khaw, Kooi Yeong and Tan, Wen-Nee (2022) Recent developments in metabolomics studies of endophytic fungi. Journal of Fungi, 8 (1). ISSN 2309-608X, DOI

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Endophytic fungi are microorganisms that colonize living plants' tissues without causing any harm. They are known as a natural source of bioactive metabolites with diverse pharmacological functions. Many structurally different chemical metabolites were isolated from endophytic fungi. Recently, the increasing trends in human health problems and diseases have escalated the search for bioactive metabolites from endophytic fungi. The conventional bioassay-guided study is known as laborious due to chemical complexity. Thus, metabolomics studies have attracted extensive research interest owing to their potential in dealing with a vast number of metabolites. Metabolomics coupled with advanced analytical tools provides a comprehensive insight into systems biology. Despite its wide scientific attention, endophytic fungi metabolomics are relatively unexploited. This review highlights the recent developments in metabolomics studies of endophytic fungi in obtaining the global metabolites picture.

Item Type: Article
Funders: Ministry of Education, Malaysia [FRGS/1/2018/STG01/USM/02/3]
Uncontrolled Keywords: Metabolomics; Endophytic fungi; Bioactive metabolites; Nuclear magnetic resonance; Liquid chromatography-high-resolution mass spectrometry; Extraction; Analytical tool; Systems biology
Subjects: Q Science > QK Botany
Q Science > QR Microbiology
Divisions: Faculty of Pharmacy > Department of Clinical Pharmacy and Pharmacy Practice
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 02 Aug 2022 00:19
Last Modified: 02 Aug 2022 00:19

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