Wound healing properties of exosomes-a review and modelling of combinatorial analysis strategies

Liew, Fong Fong and Chew, Boon Cheng and Ooi, Der Jiun (2022) Wound healing properties of exosomes-a review and modelling of combinatorial analysis strategies. Current Molecular Medicine, 22 (2). pp. 165-191. ISSN 1566-5240, DOI https://doi.org/10.2174/1566524021666210405131238.

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Wound healing is an elaborated process, well-regulated via cell migration and proliferation. Although the physiological basics of wound healing have been thoroughly investigated and reported, much remains to be studied. Particularly, various studies have demonstrated the immunomodulatory roles of exosomes derived from plant cells, mammalian cells, and mesenchymal stem cells (MSCs) in the healing and repairing system. The paracrine and therapeutic effects of exosomes are mainly associated with the broad exosomal cargo content comprising growth factors, cytokines, enzymes, nucleic acids, proteins, and lipid signaling molecules. Nevertheless, the functional or mechanism pathway of exosomes with reference to overall exosomal cargo remains undetermined. To date, combinatorial analysis strategies employing Database for Annotation, Visualization, and Integrated Discovery (DAVID), STRING tools, Gene Ontology (GO), Kyoto Encyclopedia of Genes, Genomes (KEGG) pathway enrichment analysis, as well as Ingenuity Pathway Analysis (IPA) have been applied in elucidating network interaction and functional pathway of exosomes. In this review paper, the application of combinatorial analysis strategies is demonstrated to better understand the therapeutic potentials of exosomes in the wound healing process. In conclusion, functional modulation of exosomal cargo for specific biological treatment is achievable, and modelling of combinatorial analysis strategies will hopefully bridge the research gap and provide a paradigm shift to regenerative processes.

Item Type: Article
Funders: Fundamental Research Grant Scheme, Ministry of Higher Education Malaysia [Grant No: FRGS/1/2019/SKK08/MAHSA/02/5]
Uncontrolled Keywords: Exosome; Healing; Combinatorial analysis; STRING tools; Gene ontologY; KEGG pathway; DAVID and ingenuity pathway analysis
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 27 Jul 2022 05:01
Last Modified: 27 Jul 2022 05:01
URI: http://eprints.um.edu.my/id/eprint/33562

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