C-kit expression in oral leukoplakia

Tegginamani, Anand S. and Shivakumar, Vanishree H. and Ismail, Siti Mazlipah and Abraham, Mannil T. and Fernandes, Bennete A. and Zamzuri, Ahmad Termizi B. (2022) C-kit expression in oral leukoplakia. Journal of the College of Physicians and Surgeons Pakistan, 32 (2). pp. 256-258. ISSN 1022-386X, DOI https://doi.org/10.29271/jcpsp.2022.02.256.

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Oral leukoplakia is the most common potentially malignant oral disorder. Oral leukoplakia's malignant potential is independent of the histopathological grade, and the malignant transformation rate varies greatly from 3% to 50% even in the case of severe epithelial dysplasia. Ethnic & environmental variables may contribute to this variation. C-kit immunohistochemistry was performed on 15 oral leukoplakia (OL), two oral squamous cell carcinoma (OSCC), and two dentigerous cysts (DC). The objective of this study was to evaluate the c-kit expression in oral leukoplakia. The use of various immunohistochemical markers to differentiate between OLs with a high and low risk of malignant transformation has been investigated. Only four OL exhibited a faint cytoplasmic expression in basal cells. Whereas, OSCC and DC were devoid of c-kit expression. Thus, this may not be a unique marker for identifying OL at high-risk. Further research with larger sample size is required.

Item Type: Article
Funders: SEGi University Research Grant [SEGiuni/VC/RIMC/33/19-12-2016]
Uncontrolled Keywords: CD 117; Disease progression; Oral dysplasia; Oral leukoplakia; Risk prediction
Subjects: R Medicine > R Medicine (General)
R Medicine > RK Dentistry
Divisions: Faculty of Dentistry > Dept of Oral & Maxillofacial Surgery
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 03 Aug 2022 01:26
Last Modified: 03 Aug 2022 01:26
URI: http://eprints.um.edu.my/id/eprint/33442

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