Silencing quorum sensing through extracts of Melicope lunu-ankenda

Tan, L.Y. and Yin, W.F. and Chan, Kok Gan (2012) Silencing quorum sensing through extracts of Melicope lunu-ankenda. Sensors, 12 (4). pp. 4339-4351. ISSN 1424-8220, DOI


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Quorum sensing regulates bacterial virulence determinants, therefore making it an interesting target to attenuate pathogens. In this work, we screened edible, endemic plants in Malaysia for anti-quorum sensing properties. Extracts from Melicope lunu-ankenda (Gaertn.) T. G. Hartley, a Malay garden salad, inhibited response of Chromobacterium violaceum CV026 to N-hexanoylhomoserine lactone, thus interfering with violacein production; reduced bioluminescence expression of E. coli [pSB401], disrupted pyocyanin synthesis, swarming motility and expression of lecA::lux of Pseudomonas aeruginosa PAO1. Although the chemical nature of the anti-QS compounds from M. lunu-ankenda is currently unknown, this study proves that endemic Malaysian plants could serve as leads in the search for anti-quorum sensing compounds.

Item Type: Article
Additional Information: Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia; E-Mails: (L.Y.T.); (W.-F.Y.)
Uncontrolled Keywords: Anti-quorum sensing; Bioluminescence; Leca::lux; Malaysian plants; N-acyl-l-homoserine lactones (ahl); Pseudomonas aeruginosa pao1; Pyocyanin; Virulence; Swarming motility
Subjects: Q Science > Q Science (General)
R Medicine
Divisions: Faculty of Science > Institute of Biological Sciences
Depositing User: Mr. Faizal Hamzah
Date Deposited: 18 Jun 2012 02:22
Last Modified: 30 Oct 2018 01:54

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