“Mummy, my eyelids are heavy”: A case series of juvenile myasthenia gravis

Krishna, L. and Abdul Jalil, N.F. and Lott, P.W. and Singh, S. and Choo, M.M. (2021) “Mummy, my eyelids are heavy”: A case series of juvenile myasthenia gravis. European Journal of Ophthalmology, 31 (2). NP119-NP122. ISSN 1120-6721, DOI https://doi.org/10.1177/1120672119867605.

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Abstract

Purpose: To report three cases of juvenile myasthenia gravis aged between 18 and 24 months with ocular symptoms as their first presentation. Method: A case series. Results: We present a case series of juvenile myasthenia gravis in a tertiary centre in Malaysia. Two of the three cases consist of a pair of twins who presented with ptosis of bilateral eyes; the first twin presented 4 months later than the second twin. These two cases were positive for anti-acetylcholine receptor antibodies and had generalized myasthenia gravis, whereas the other case was negative for receptor antibodies and was purely ocular myasthenia gravis. Conclusion: Juvenile myasthenia gravis is relatively rare in toddlers. Early diagnosis and commencement of treatment is important to slow the progression of the disease and avoiding life-threatening events. © The Author(s) 2019.

Item Type: Article
Funders: None
Uncontrolled Keywords: Cholinergic receptor antibody; Immunoglobulin; Prednisolone; Pyridostigmine; Autoantibody; Cholinergic receptor; Cholinesterase inhibitor; Glucocorticoid; Prednisolone; Pyridostigmine, Antibody titer; Article; Case report; Child; Clinical article; Divergent strabismus; Eye movement; Eyelid; Female; Human; Juvenile myasthenia gravis; Multiple cycle treatment; Myasthenia gravis; Nuclear magnetic Resonance imaging; Plasmapheresis; Pneumonia; Preschool child; Ptosis (Eyelid); Visual acuity; Blood; Combination drug therapy; Genetics; Immunology; Infant; Monozygotic twins; Myasthenia gravis; Ptosis; Twins, Autoantibodies; Blepharoptosis; Child, Preschool; Cholinesterase inhibitors; Diseases In twins; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Infant; Myasthenia Gravis; Prednisolone; Pyridostigmine bromide; Receptors, Cholinergic; Twins, Monozygotic
Subjects: R Medicine > RE Ophthalmology
Divisions: Faculty of Medicine > Ophthalmplogy Department
Depositing User: Ms Zaharah Ramly
Date Deposited: 21 Apr 2022 03:43
Last Modified: 21 Apr 2022 04:35
URI: http://eprints.um.edu.my/id/eprint/28877

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