Prevalence and risk assessment of antibiotics in riverine estuarine waters of Larut and Sangga Besar River, Perak

Low, Kyleyoung and Layching, Chai and Choonweng, Lee and Gan, Zhang and Ruijie, Zhang and Vahab, Vaezzadeh and Chuiwei, Bong (2021) Prevalence and risk assessment of antibiotics in riverine estuarine waters of Larut and Sangga Besar River, Perak. Journal of Oceanology and Limnology, 39 (1). pp. 122-134. ISSN 2096-5508, DOI

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Antibiotics released into the environment through anthropogenic activities exert selective pressure, driving bacteria towards increasing antimicrobial resistance. The prevalence of antibiotics and the ecological risks posed in the riverine estuarine of Larut River and Sangga Besar River, which included wastewater effluents from hospital, zoo, and poultry slaughterhouse sources were investigated. Solid phase extraction (SPE) followed by high-performance liquid chromatography tandem mass chromatography (HPLC-MS/MS) were used to extract and quantify the antibiotic residues from 22 antibiotics belonging to six major antibiotic classes (sulfonamide, macrolide, fluoroquinolone, phenicol, trimethoprim, and tetracycline). Sixteen antibiotic residues were detected with concentrations ranging from limit of detection (LOD) to 1 262.3 ng/L. Fluoroquinolones and macrolides were the most frequently detected compounds. Erythromycin, clarithromycin, and ofloxacin detected in hospital and zoo effluents posed a high risk to algae while tetracycline had low to medium ecological risks toward all the relevant organisms from aquatic environments (algae, invertebrate Daphnia magna, and fish).

Item Type: Article
Funders: Ministry of Education, Malaysia[IOES2014D], Ministry of Education, Malaysia[FP048-2013A], Ministry of Education, Malaysia[SF022-2013]
Uncontrolled Keywords: Antibiotic residues;Prevalence;Ecological risk;Anthropogenic pollution;Riverine;Estuarine
Subjects: G Geography. Anthropology. Recreation > GC Oceanography
G Geography. Anthropology. Recreation > GE Environmental Sciences
Q Science > Q Science (General)
Divisions: Faculty of Science
Depositing User: Ms Zaharah Ramly
Date Deposited: 18 Aug 2022 02:19
Last Modified: 18 Aug 2022 02:19

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