Recent advances in scaffolding from natural-based polymers for volumetric muscle injury

Nuge, Tamrin and Liu, Ziqian and Liu, Xiaoling and Ang, Bee Chin and Andriyana, Andri and Metselaar, Hendrik Simon Cornelis and Hoque, Md Enamul (2021) Recent advances in scaffolding from natural-based polymers for volumetric muscle injury. Molecules, 26 (3). ISSN 1420-3049, DOI

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Volumetric Muscle Loss (VML) is associated with muscle loss function and often untreated and considered part of the natural sequelae of trauma. Various types of biomaterials with different physical and properties have been developed to treat VML. However, much work remains yet to be done before the scaffolds can pass from the bench to the bedside. The present review aims to provide a comprehensive summary of the latest developments in the construction and application of natural polymers-based tissue scaffolding for volumetric muscle injury. Here, the tissue engineering approaches for treating volumetric muscle loss injury are highlighted and recent advances in cell-based therapies using various sources of stem cells are elaborated in detail. An overview of different strategies of tissue scaffolding and their efficacy on skeletal muscle cells regeneration and migration are presented. Furthermore, the present paper discusses a wide range of natural polymers with a special focus on proteins and polysaccharides that are major components of the extracellular matrices. The natural polymers are biologically active and excellently promote cell adhesion and growth. These bio-characteristics justify natural polymers as one of the most attractive options for developing scaffolds for muscle cell regeneration.

Item Type: Article
Funders: Ningbo Science and Technology bureau [Grant No: 2017D10030]
Uncontrolled Keywords: Volumetric muscle loss (VML); Tissue engineering; Electrospun; Hydrogels; Acellular; Stem cells
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Engineering
Depositing User: Ms Zaharah Ramly
Date Deposited: 21 Apr 2022 02:41
Last Modified: 21 Apr 2022 04:37

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