Ocular surface disease in psoriatic patients in a developing country

Goh, Yihui and Kwan, Zhenli and Han, Winn Hui and Iqbal, Tajunisah and Yahya, Fariz and Khang, Tsung Fei and Singh, Sujaya (2021) Ocular surface disease in psoriatic patients in a developing country. International Ophthalmology, 41 (6). pp. 2139-2147. ISSN 0165-5701, DOI https://doi.org/10.1007/s10792-021-01771-8.

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Purpose To evaluate ocular surface changes among patients with psoriasis in Malaysia, a developing country in Southeast Asia. Methods An interdisciplinary case-control study (60 psoriasis patients and 40 control subjects) to look at the differences in ocular surface manifestations between patients with psoriasis and a group of age-, gender- and ethnicity-matched healthy controls. Results One hundred and twenty eyes of 60 patients with psoriasis and 80 eyes of 40 healthy controls without psoriasis were included in the study. Mild-to-moderate psoriasis was found in 42 patients (70%), while 18 patients (30%) had severe psoriasis. Psoriatic arthritis was found in 19 patients (32%). Of the 60 psoriatic patients, the prevalence of ocular involvement was 65% (39/60), in which 32% (19/60) had dry eyes, 27% (16/60) had lid margin abnormalities, 33% (20/60) had cataract, and one had history of anterior uveitis. Compared to controls, ocular surface of psoriatic patients showed more eyelid margin abnormalities, higher meibomian gland loss and lower tear film break-up time. The estimated odds ratio for dry eyes in the psoriasis group was 2.2 (95% CI: 0.8-6.9). Conclusion Ocular surface disorders encompassing eyelid margin abnormalities, meibomian gland loss and tear dysfunction occur at an earlier and higher rate among psoriatic patients.

Item Type: Article
Funders: Universiti Malaya [Grant No: BK035-2018]
Uncontrolled Keywords: Psoriasis; Psoriatic arthritis; Ocular surface; Dry eye; Meibography; Malaysia
Subjects: R Medicine > RE Ophthalmology
Divisions: Faculty of Medicine
Faculty of Science
Depositing User: Ms Zaharah Ramly
Date Deposited: 21 Apr 2022 06:03
Last Modified: 21 Apr 2022 06:03
URI: http://eprints.um.edu.my/id/eprint/28828

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