Label-free surface-plasmon resonance fiber grating biosensor for Hand-foot-mouth disease (EV-A71) detection

Udos, Waldo and Ooi, Cheong-Weng and Tan, Soon-Hao and Lim, Kok-Sing and Ee, Yen Jie and Ong, Kien Chai and Ahmad, Harith (2021) Label-free surface-plasmon resonance fiber grating biosensor for Hand-foot-mouth disease (EV-A71) detection. Optik, 228. ISSN 0030-4026, DOI

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In this work, we have demonstrated the surface plasmon resonance tilted fiber Bragg grating (SPR-TFBG) based biosensor for the detection of Enterovirus A71, one of the causative agents for Hand-foot-mouth disease. The SPR-TFBG was biofunctionalized with monoclonal antibody (MAb), a bioreceptor that has an affinity for the virus. Beside the virus concentrations, the other unknown substance in the test analytes can contribute to the refractive index noise that has a significant impact to the sensor signal and accuracy of the measurement. In the experiment, a rinsing step is incorporated in the test with EV-A71 virus solution followed by the measurement of the optical spectrum in baseline solution with fixed refractive index. This procedure can effectively eliminate the refractive index noise and enhance the specificity of the signal to the target virus.

Item Type: Article
Funders: Impact Oriented Interdisciplinary Research Grant [llRG028A-2019], Ministry of Education, Malaysia [ FRGS 019/2016]
Uncontrolled Keywords: Tilted fiber Bragg grating (TFBG) biosensor; Immunosensor; Refractive index noise; Surface plasmon resonance
Subjects: R Medicine > R Medicine (General)
R Medicine > RE Ophthalmology > Ophthalmology
Divisions: Faculty of Medicine > School of Biological Sciences
Depositing User: Ms Zaharah Ramly
Date Deposited: 20 Apr 2022 06:19
Last Modified: 20 Apr 2022 06:19

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