Cytotoxic triterpenoids from the stem bark of Aglaia angustifolia

Hutagaol, Ricson Pemimpin and Harneti, Desi and Safari, Agus and Hidayat, Ace Tatang and Supratman, Unang and Awang, Khalijah and Shiono, Yoshihito (2021) Cytotoxic triterpenoids from the stem bark of Aglaia angustifolia. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 23 (8). pp. 781-788. ISSN 1028-6020, DOI

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A seco-apotirucallane-type triterpenoid, namely angustifolianin (1), along with three dammarane-type triterpenoids, (20S, 24S)-epoxy-dammarane-3 beta,25-diol (2), 3-epi-cabraleahydroxylactone (3), and cabralealactone (4), were isolated from the stem bark ofAglaia angustifoliaMiq. The Chemical structure of the new compounds was elucidated on the basis of spectroscopic data. All of the compounds were evaluated for their cytotoxic effects against MCF-7 breast cancer cells. Among those compounds, angustifolianin (1)showed strongest cytotoxic activity with an IC(50)value of 50.5 mu g/ml.

Item Type: Article
Uncontrolled Keywords: Aglaia angustifolia; Angustifolianin; MCF-7; Meliaceae; Seco-apotirucallane
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science > Department of Chemistry
Depositing User: Ms Zaharah Ramly
Date Deposited: 23 Mar 2022 08:24
Last Modified: 23 Mar 2022 08:24

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