A review on plant flavonoids as potential anticancer agents

Kapoor, Bhupinder and Gulati, Monica and Gupta, Reena and Singh, Sachin Kumar and Gupta, Mukta and Nabi, Arshid and Chawla, Pooja A. (2021) A review on plant flavonoids as potential anticancer agents. Current Organic Chemistry, 25 (6). pp. 737-747. ISSN 1385-2728, DOI https://doi.org/10.2174/1385272824999201126214150.

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Flavonoids are polyphenolic compounds that are mainly derived from fruits and vegetables and constitute an essential part of plant-derived beverages such as green tea, wine and cocoa-based products. They have been shown to possess anticancer effects via different mechanisms such as carcinogen inactivation, antiproliferation, cell cycle arrest, induction of apoptosis and differentiation, inhibition of angiogenesis, anti-oxidation and reversal of multidrug resistance or a combination of any two or more of these mechanisms. The present review summarizes the chemistry, biosynthesis and anticancer evaluation of flavonoids in both animal and human studies. A special emphasis has been placed on the flavonoids that are being screened in different phases of clinical trials for chemopmtective action against various cancers.

Item Type: Article
Uncontrolled Keywords: Flavonoids; anticancer; Chemoprotection; Clinical trials; Apoptosis; Antiproliferation
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Divisions: Faculty of Science > Department of Chemistry
Depositing User: Ms Zaharah Ramly
Date Deposited: 16 Aug 2022 07:57
Last Modified: 16 Aug 2022 07:57
URI: http://eprints.um.edu.my/id/eprint/28645

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