Zinc oxide-quercetin nanocomposite as a smart nano-drug delivery system: Molecular-level interaction studies

Sathishkumar, Palanivel and Li, Zhaofa and Govindan, Raji and Jayakumar, Rajarajeswaran and Wang, Chaoyang and Gu, Feng Long (2021) Zinc oxide-quercetin nanocomposite as a smart nano-drug delivery system: Molecular-level interaction studies. Applied Surface Science, 536. ISSN 0169-4332, DOI https://doi.org/10.1016/j.apsusc.2020.147741.

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In this study, zinc oxide-quercetin (ZnO-quercetin) nanocomposite was constructed as smart nano-drug delivery system. The amount of quercetin loaded onto the ZnO nanoparticle was found to be 210 mu g mg(-1). The quercetin release kinetics data indicates that the rate of quercetin release was faster in acidic condition (pH of typical cancer) compared to physiological condition. The molecular-level interaction of ZnO-quercetin nanocomposite formation was investigated by a combined experimental and theoretical investigation. The interaction studies have corroborated that 5-OH in the A-ring and 3-OH in the C-ring of quercetin were the most suitable positions for the ZnO interaction. The constructed ZnO-quercetin nanocomposite demonstrates an effective inhibition of the growth of breast cancer cells (MCF-7) with high biocompatibility (3T3-L1 cells). This study may provide a model path for the further development of smart nano-drug delivery system of metal oxides with hydrophobic natural drugs to treat cancer cells.

Item Type: Article
Funders: National Natural Science Foundation of China (NSFC) [21673085], Science and Technology Planning Project of Guangdong Province [2013B051000074 ], Guangdong-Hong Kong Technology Cooperation Funding Scheme [2017A050506048], Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme
Uncontrolled Keywords: Density functional theory; Flavonoids; Molecular interaction; Drug delivery system; Quercetin; Zinc oxide nanoparticles
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine > School of Medicine
Depositing User: Ms Zaharah Ramly
Date Deposited: 15 Aug 2022 02:57
Last Modified: 15 Aug 2022 02:57
URI: http://eprints.um.edu.my/id/eprint/28539

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