IL-1 alpha and colorectal cancer pathogenesis: Enthralling candidate for anti-cancer therapy

Cheng, Kim Jun and Mohammed, Elsa Haniffah Mejia and Khong, Tak Loon and Zain, Shamsul Mohd and Thavagnanam, Surendran and Ibrahim, Zaridatul Aini (2021) IL-1 alpha and colorectal cancer pathogenesis: Enthralling candidate for anti-cancer therapy. Critical Reviews In Oncology Hematology, 163. ISSN 1040-8428, DOI

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Inflammation has been well-established as a hallmark of colorectal cancer (CRC). Interleukin-1 alpha (IL-1 alpha) is one of the primary inflammatory mediators driving the pathogenesis of inflammation-associated CRC. This systematic review presents the roles of IL-1 alpha in the pathogenesis of the disease. Bibliographic databases PubMed, Science Direct, Scopus and Web of Science were systematically searched for articles that addresses the relationship between IL-1 alpha and colorectal cancer. We highlighted various mechanisms by which IL-1 alpha promotes the pathogenesis of CRC including enhancement of angiogenesis, metastasis, resistance to therapy, and inhibition of tumour suppressive genes. We also discussed the potential mechanisms by which IL-1 alpha expression is induced or secreted in various studies. Beyond these, the systematic review also highlights several potential therapeutic strategies which should be further explored in the future; to target IL-1 alpha and/or its associated pathways; paving our way in finding effective treatments for CRC patients.

Item Type: Article
Funders: Universiti Malaya Faculty Research Grant [GPF006C-2019]
Uncontrolled Keywords: Colorectal cancer; Interleukin-1 alpha; DAMP; Inflammation; Metastasis; Cancer; Cytokine; Targeted therapy
Subjects: R Medicine > R Medicine (General)
R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Medicine
Depositing User: Ms Zaharah Ramly
Date Deposited: 30 Jul 2022 01:13
Last Modified: 30 Jul 2022 01:13

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