Hijacking of the host's immune surveillance radars by burkholderia pseudomallei

Mariappan, Vanitha and Vellasamy, Kumutha Malar and Barathan, Muttiah and Girija, A. S. Smiline and Shankar, Esaki M. and Vadivelu, Jamuna (2021) Hijacking of the host's immune surveillance radars by burkholderia pseudomallei. Frontiers in Immunology, 12. ISSN 1664-3224, DOI https://doi.org/10.3389/fimmu.2021.718719.

Full text not available from this repository.


Burkholderia pseudomallei (B. pseudomallei) causes melioidosis, a potentially fatal disease for which no licensed vaccine is available thus far. The host-pathogen interactions in B. pseudomallei infection largely remain the tip of the iceberg. The pathological manifestations are protean ranging from acute to chronic involving one or more visceral organs leading to septic shock, especially in individuals with underlying conditions similar to COVID-19. Pathogenesis is attributed to the intracellular ability of the bacterium to `step into' the host cell's cytoplasm from the endocytotic vacuole, where it appears to polymerize actin filaments to spread across cells in the closer vicinity. B. pseudomallei effectively evades the host's surveillance armory to remain latent for prolonged duration also causing relapses despite antimicrobial therapy. Therefore, eradication of intracellular B. pseudomallei is highly dependent on robust cellular immune responses. However, it remains ambiguous why certain individuals in endemic areas experience asymptomatic seroconversion, whereas others succumb to sepsis-associated sequelae. Here, we propose key insights on how the host's surveillance radars get commandeered by B. pseudomallei.

Item Type: Article
Funders: University of Malaya Impact-Oriented Interdisciplinary Research Grant by Ministry of Higher Education - University of Malaya [IIRG019-2019], Frontiers Research Grant [FG012-17AFR], Department of Science and TechnologyScience and Engineering Research Board, Government of India [CRG/2019/006096]
Uncontrolled Keywords: Burkholderia pseudomallei; Immunology; Melioidosis; Pathogenesis; Virulence
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine
Depositing User: Ms Zaharah Ramly
Date Deposited: 29 Jul 2022 14:26
Last Modified: 29 Jul 2022 14:26
URI: http://eprints.um.edu.my/id/eprint/28292

Actions (login required)

View Item View Item