Feature selection methods for optimizing clinicopathologic input variables in oral cancer prognosis

Chang, S.W. and Kareem, S.A. and Kallarakkal, A.F. and Merican, A.F. and Abraham, M.T. and Zain, R.B. (2011) Feature selection methods for optimizing clinicopathologic input variables in oral cancer prognosis. Asian Pacific Journal of Cancer Prevention, 12 (10). ISSN 1513-7368, DOI PMID: 22320970.

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Official URL: http://www.ncbi.nlm.nih.gov/pubmed/22320970


The incidence of oral cancer is high for those of Indian ethnic origin in Malaysia. Various clinical and pathological data are usually used in oral cancer prognosis. However, due to time, cost and tissue limitations, the number of prognosis variables need to be reduced. In this research, we demonstrated the use of feature selection methods to select a subset of variables that is highly predictive of oral cancer prognosis. The objective is to reduce the number of input variables, thus to identify the key clinicopathologic (input) variables of oral cancer prognosis based on the data collected in the Malaysian scenario. Two feature selection methods, genetic algorithm (wrapper approach) and Pearson's correlation coefficient (filter approach) were implemented and compared with single-input models and a full-input model. The results showed that the reduced models with feature selection method are able to produce more accurate prognosis results than the full-input model and single-input model, with the Pearson's correlation coefficient achieving the most promising results.

Item Type: Article
Additional Information: Department of Artificial Intelligence, Faculty of Computer Science and Information Technology and Bioinformatics Division, Institute of Biological Science, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia E-mail
Uncontrolled Keywords: Oral Cancer
Subjects: R Medicine
Divisions: Faculty of Computer Science & Information Technology
Depositing User: Mr. Faizal Hamzah
Date Deposited: 27 Feb 2012 01:58
Last Modified: 11 Nov 2013 01:27
URI: http://eprints.um.edu.my/id/eprint/2798

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