Exploring the role and potential of probiotics in the field of mental health: Major depressive disorder

Johnson, Dinyadarshini and Thurairajasingam, Sivakumar and Letchumanan, Vengadesh and Chan, Kok-Gan and Lee, Learn-Han (2021) Exploring the role and potential of probiotics in the field of mental health: Major depressive disorder. Nutrients, 13 (5). ISSN 2072-6643, DOI https://doi.org/10.3390/nu13051728.

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The field of probiotic has been exponentially expanding over the recent decades with a more therapeutic-centered research. Probiotics mediated microbiota modulation within the microbiota-gut-brain axis (MGBA) have been proven to be beneficial in various health domains through pre-clinical and clinical studies. In the context of mental health, although probiotic research is still in its infancy stage, the promising role and potential of probiotics in various mental disorders demonstrated via in-vivo and in-vitro studies have laid a strong foundation for translating preclinical models to humans. The exploration of the therapeutic role and potential of probiotics in major depressive disorder (MDD) is an extremely noteworthy field of research. The possible etio-pathological mechanisms of depression involving inflammation, neurotransmitters, the hypothalamic-pituitary-adrenal (HPA) axis and epigenetic mechanisms potentially benefit from probiotic intervention. Probiotics, both as an adjunct to antidepressants or a stand-alone intervention, have a beneficial role and potential in mitigating anti-depressive effects, and confers some advantages compared to conventional treatments of depression using anti-depressants.

Item Type: Article
Funders: Jeffrey Cheah School of Medicine and Health Sciences (JCSMHS) SEED Fund 2020, PVC Award Grant [PVC-ECR-2016], External Industry Grant (Biotek Abadi) [GBA-808138] [GBA-808813], University of Malaya Research Grant (FRGS Grant) [FP022-2018A]
Uncontrolled Keywords: Probiotic; Microbiota; Major depressive disorder; Epigenetic; Antidepressant;
Subjects: R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Science > Institute of Biological Sciences
Depositing User: Ms Zaharah Ramly
Date Deposited: 13 Apr 2022 00:24
Last Modified: 13 Apr 2022 00:39
URI: http://eprints.um.edu.my/id/eprint/27934

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