Nicotinamide phosphoribosyltransferase as a key molecule of the aging/senescence process

Khaidizar, Fiqri Dizar and Bessho, Yasumasa and Nakahata, Yasukazu (2021) Nicotinamide phosphoribosyltransferase as a key molecule of the aging/senescence process. International Journal of Molecular Sciences, 22 (7). ISSN 1422-0067, DOI

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Aging is a phenomenon underlined by complex molecular and biochemical changes that occur over time. One of the metabolites that is gaining strong research interest is nicotinamide adenine dinucleotide, NAD(+), whose cellular level has been shown to decrease with age in various tissues of model animals and humans. Administration of NAD(+) precursors, nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR), to supplement NAD(+) production through the NAD(+) salvage pathway has been demonstrated to slow down aging processes in mice. Therefore, NAD(+) is a critical metabolite now understood to mitigate age-related tissue function decline and prevent age-related diseases in aging animals. In human clinical trials, administration of NAD(+) precursors to the elderly is being used to address systemic age-associated physiological decline. Among NAD(+) biosynthesis pathways in mammals, the NAD(+) salvage pathway is the dominant pathway in most of tissues, and NAMPT is the rate limiting enzyme of this pathway. However, only a few activators of NAMPT, which are supposed to increase NAD(+), have been developed so far. In this review, we will focus on the importance of NAD(+) and the possible application of an activator of NAMPT to promote successive aging.

Item Type: Article
Funders: Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research (KAKENHI) (17K08569)
Uncontrolled Keywords: NAD(+); NAMPT; NMN; NR; NMNH; aging; senescence; SBI-797812; PNGL; IRW
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
Divisions: Deputy Vice Chancellor (Research & Innovation) Office > Centre for Research in Biotechnology for Agriculture
Depositing User: Ms Zaharah Ramly
Date Deposited: 31 May 2022 02:01
Last Modified: 31 May 2022 02:01

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